Literature DB >> 2069565

Occurrence of cholesterol 7 alpha- and 7 beta-hydroperoxides in rat skin as aging markers.

N Ozawa1, S Yamazaki, K Chiba, H Aoyama, H Tomisawa, M Tateishi, T Watabe.   

Abstract

Evidence for presence of cholesterol 7 alpha- and 7 beta-hydroperoxides in rat skin was presented for the first time. The 7-hydroperoxides in rat skin were reduced with sodium borohydride and trimethylsilylated for identification with the authentic compounds by gas chromatography/mass spectrometry. A content of cholesterol 7-hydroperoxides in rat skin, determined by high performance liquid chromatography with a chemiluminescence detector, highly correlated with the age of rats (r = 0.874; between 1 and 45 weeks old), indicating that cholesterol 7 alpha- and 7 beta-hydroperoxides were good markers for aging.

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Year:  1991        PMID： 2069565     DOI： 10.1016/0006-291x(91)91805-m

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

Review 1.  Review of progress in sterol oxidations: 1987-1995.

Authors:  L L Smith
Journal:  Lipids       Date:  1996-05       Impact factor: 1.880

2.  Chemiluminescent determination of cholesterol hydroperoxides in human erythrocyte membrane.

Authors:  J Adachi; M Asano; T Naito; Y Ueno; Y Tatsuno
Journal:  Lipids       Date:  1998-12       Impact factor: 1.880

Review 3.  Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Authors:  F Oesch; E Fabian; Robert Landsiedel
Journal:  Arch Toxicol       Date:  2018-06-18       Impact factor: 5.153

4.  Cholesterol-derived hydroperoxides in alcoholic liver disease.

Authors:  M Asano; J Adachi; Y Ueno
Journal:  Lipids       Date:  1999-06       Impact factor: 1.880

Review 5.  Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Authors:  F Oesch; E Fabian; K Guth; R Landsiedel
Journal:  Arch Toxicol       Date:  2014-11-05       Impact factor: 5.153

6.  Identification of core aldehydes among in vitro peroxidation products of cholesteryl esters.

Authors:  H Kamido; A Kuksis; L Marai; J J Myher
Journal:  Lipids       Date:  1993-04       Impact factor: 1.880

7.  7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein.

Authors:  G M Chisolm; G Ma; K C Irwin; L L Martin; K G Gunderson; L F Linberg; D W Morel; P E DiCorleto
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

8.  Combination of TLC blotting and gas chromatography-mass spectrometry for analysis of peroxidized cholesterol.

Authors:  Yuko Minami; Sayuri Yokoi; Mari Setoyama; Noriko Bando; Sayaka Takeda; Yoshichika Kawai; Junji Terao
Journal:  Lipids       Date:  2007-08-15       Impact factor: 1.880

9.  Metabolism of fatty acids and lipid hydroperoxides in human body monitoring with Fourier transform Infrared Spectroscopy.

Authors:  Satoshi Yoshida; Qin-Zeng Zhang; Shu Sakuyama; Satoshi Matsushima
Journal:  Lipids Health Dis       Date:  2009-07-24       Impact factor: 3.876
  9 in total

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