Literature DB >> 20694486

Confirmation rate of blinded (99m)Tc-SPECT compared to neurochemical dementia biomarkers in CSF in patients with Alzheimer disease.

Daniela Schmidt1, Rüdiger Zimmermann, Piotr Lewczuk, Gerd Schaller, Umüt Degirmenci, Sebastian Kreil, Jens Wiltfang, Torsten Kuwert, Johannes Kornhuber, Markus Weih.   

Abstract

In Alzheimer disease, CSF biomarkers and nuclear imaging are of particular interest. Many studies investigated only one technique, limiting comparison. Here, in 76 patients blinded 99mTc-SPECT was compared to CSF. Sensitivity of CSF was 92%; and 51% for SPECT. Specificity favored SPECT (90 vs. 80%). Both techniques showed no coherence (p = 0.17-0.47). Our results confirm that CSF biomarkers show higher sensitivity. SPECT has higher specificity and can also be used for other dementias without established CSF biomarkers.

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Year:  2010        PMID： 20694486     DOI： 10.1007/s00702-010-0459-7

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  19 in total

1.  [The differential diagnosis of dementia--a remaining challenge].

Authors:  G R Fink
Journal:  Fortschr Neurol Psychiatr       Date:  2008-08       Impact factor: 0.752

2.  Accurate prediction of histologically confirmed Alzheimer's disease and the differential diagnosis of dementia: the use of NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and Apo E4 in medial temporal lobe dementias. Oxford Project to Investigate Memory and Aging.

Authors:  K A Jobst; L P Barnetson; B J Shepstone
Journal:  Int Psychogeriatr       Date:  1998-09       Impact factor: 3.878

3.  Optimized data preprocessing for multivariate analysis applied to 99mTc-ECD SPECT data sets of Alzheimer's patients and asymptomatic controls.

Authors:  Dorit Merhof; Pawel J Markiewicz; Günther Platsch; Jerome Declerck; Markus Weih; Johannes Kornhuber; Torsten Kuwert; Julian C Matthews; Karl Herholz
Journal:  J Cereb Blood Flow Metab       Date:  2010-07-14       Impact factor: 6.200

4.  Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD.

Authors:  K Lobotesis; J D Fenwick; A Phipps; A Ryman; A Swann; C Ballard; I G McKeith; J T O'Brien
Journal:  Neurology       Date:  2001-03-13       Impact factor: 9.910

5.  Correlation of rCBF (SPECT), CSF tau, and cognitive function in patients with dementia of the Alzheimer's type, other types of dementia, and control subjects.

Authors:  M Tsolaki; V Sakka; G Gerasimou; N Dimacopoulos; O Chatzizisi; K N Fountoulakis; G Kyriazis; J Papanastasiou; A Kazis
Journal:  Am J Alzheimers Dis Other Demen       Date:  2001 Jan-Feb       Impact factor: 2.035

6.  Combined Analysis of CSF Tau Levels and [(123)I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer's Disease.

Authors:  Nobuyuki Okamura; Hiroyuki Arai; Masahiro Maruyama; Makoto Higuchi; Toshifumi Matsui; Haruko Tanji; Takashi Seki; Hisao Hirai; Hiroshi Chiba; Masatoshi Itoh; Hidetada Sasaki
Journal:  Am J Psychiatry       Date:  2002-03       Impact factor: 18.112

7.  Consecutive brain SPECT surface three-dimensional displays show progression of cerebral cortical abnormalities in Alzheimer's disease

Authors: 
Journal:  Clin Nucl Med       Date:  1999-10       Impact factor: 7.794

8.  Neurochemical dementia diagnostics: a simple algorithm for interpretation of the CSF biomarkers.

Authors:  Piotr Lewczuk; Rüdiger Zimmermann; Jens Wiltfang; Johannes Kornhuber
Journal:  J Neural Transm (Vienna)       Date:  2009-08-04       Impact factor: 3.575

Review 9.  Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia.

Authors:  Nadine J Dougall; Sjoerd Bruggink; Klaus P Ebmeier
Journal:  Am J Geriatr Psychiatry       Date:  2004 Nov-Dec       Impact factor: 4.105

10.  Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease: original data and review of the literature.

Authors:  Piotr Lewczuk; Hermann Esselmann; Mirko Bibl; Georg Beck; Juan Manuel Maler; Markus Otto; Johannes Kornhuber; Jens Wiltfang
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 2.866
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  1 in total

1.  Perfusion Imaging with SPECT in the Era of Pathophysiology-Based Biomarkers for Alzheimer's Disease.

Authors:  Markus Weih; Umüt Degirmenci; Sebastian Kreil; Piotr Lewczuk; Daniela Schmidt; Johannes Kornhuber; Torsten Kuwert
Journal:  Int J Alzheimers Dis       Date:  2010-12-15
  1 in total

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