Pedro Weslley Rosario1. 1. Santa Casa de Belo Horizonte, Departamento de Neuroendocrinologia, Santa Casa de Belo Horizonte, MG, Brazil. pedrorosario@globo.com
Abstract
OBJECTIVE: To determine the normal values of serum IGF-1 (Immulite 2000) in a Brazilian adult (21-70 years) population. SUBJECTS AND METHODS: Healthy volunteers were divided into 10 groups according to age (5-year intervals), with 100 subjects (50 men and 50 women) per group. One-hundred participants were selected for repetition of the test after 12 weeks. RESULTS: No difference in IGF-1 values was observed between men and women, but a progressive reduction of serum IGF-1 with age was seen. The reference values provided by the manufacturer of the assay, although discretely higher, were very close to the values found in this study. A second measurement of IGF-1 after 12 weeks revealed a variation < 20% in 99% of subjects. CONCLUSIONS: This study established the reference range for IGF-1 determined with the Immulite 2000 assay for a large number of healthy Brazilian adults stratified according to age, and suggests that variations > 20% in IGF-1 levels within an interval of 12 weeks cannot be attributed to interassay variability.
OBJECTIVE: To determine the normal values of serum IGF-1 (Immulite 2000) in a Brazilian adult (21-70 years) population. SUBJECTS AND METHODS: Healthy volunteers were divided into 10 groups according to age (5-year intervals), with 100 subjects (50 men and 50 women) per group. One-hundred participants were selected for repetition of the test after 12 weeks. RESULTS: No difference in IGF-1 values was observed between men and women, but a progressive reduction of serum IGF-1 with age was seen. The reference values provided by the manufacturer of the assay, although discretely higher, were very close to the values found in this study. A second measurement of IGF-1 after 12 weeks revealed a variation < 20% in 99% of subjects. CONCLUSIONS: This study established the reference range for IGF-1 determined with the Immulite 2000 assay for a large number of healthy Brazilian adults stratified according to age, and suggests that variations > 20% in IGF-1 levels within an interval of 12 weeks cannot be attributed to interassay variability.
Authors: Hsin-Chieh Yeh; Nisa M Maruthur; Nae-Yuh Wang; Gerald J Jerome; Arlene T Dalcin; Eva Tseng; Karen White; Edgar R Miller; Stephen P Juraschek; Noel T Mueller; Jeanne Charleston; Nowella Durkin; Ahmed Hassoon; Dina G Lansey; Norma F Kanarek; Michael A Carducci; Lawrence J Appel Journal: J Clin Endocrinol Metab Date: 2021-09-27 Impact factor: 5.958
Authors: Luciana Silva Rodrigues; Mariana Andrea Hacker; Ximena Illarramendi; Maria Fernanda Miguens Castelar Pinheiro; José Augusto da Costa Nery; Euzenir Nunes Sarno; Maria Cristina Vidal Pessolani Journal: BMC Infect Dis Date: 2011-12-13 Impact factor: 3.090