Literature DB >> 20694106

A practical guide to diagnosis, management and treatment of testosterone deficiency for Canadian physicians.

Alvaro Morales1, Anthony J Bella, Samuel Chun, Jay Lee, Peter Assimakopoulos, Richard Bebb, Irv Gottesman, Pierre Alarie, Hélène Dugré, Stacy Elliott.   

Abstract

The percentage of men receiving appropriate management for testosterone deficiency syndrome (TDS) is small in comparison to prevalence estimates. This is despite linkages to cardiovascular disease, osteoporosis, diabetes, sexual function, sarcopenia, emotional well-being and the metabolic syndrome. Furthermore, the availability of guidelines has not significantly enhanced the care of TDS patients. A multidisciplinary group of medical experts sought to improve the management of testosterone-deficient patients by Canadian physicians. This report describes their conclusions and defines an algorithm for appropriate TDS management.

Entities:  

Year:  2010        PMID: 20694106      PMCID: PMC2910774          DOI: 10.5489/cuaj.880

Source DB:  PubMed          Journal:  Can Urol Assoc J        ISSN: 1911-6470            Impact factor:   1.862


  46 in total

1.  A critical evaluation of simple methods for the estimation of free testosterone in serum.

Authors:  A Vermeulen; L Verdonck; J M Kaufman
Journal:  J Clin Endocrinol Metab       Date:  1999-10       Impact factor: 5.958

2.  Effect of testosterone treatment on bone mineral density in men over 65 years of age.

Authors:  P J Snyder; H Peachey; P Hannoush; J A Berlin; L Loh; J H Holmes; A Dlewati; J Staley; J Santanna; S C Kapoor; M F Attie; J G Haddad; B L Strom
Journal:  J Clin Endocrinol Metab       Date:  1999-06       Impact factor: 5.958

Review 3.  Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline.

Authors:  Shalender Bhasin; Glenn R Cunningham; Frances J Hayes; Alvin M Matsumoto; Peter J Snyder; Ronald S Swerdloff; Victor M Montori
Journal:  J Clin Endocrinol Metab       Date:  2010-06       Impact factor: 5.958

4.  Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone.

Authors:  D I Spratt; L S O'Dea; D Schoenfeld; J Butler; P N Rao; W F Crowley
Journal:  Am J Physiol       Date:  1988-05

5.  Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men.

Authors:  R S Swerdloff; C Wang; G Cunningham; A Dobs; A Iranmanesh; A M Matsumoto; P J Snyder; T Weber; J Longstreth; N Berman
Journal:  J Clin Endocrinol Metab       Date:  2000-12       Impact factor: 5.958

6.  Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men.

Authors:  C Wang; R S Swerdloff; A Iranmanesh; A Dobs; P J Snyder; G Cunningham; A M Matsumoto; T Weber; N Berman
Journal:  J Clin Endocrinol Metab       Date:  2000-08       Impact factor: 5.958

7.  Validation of a screening questionnaire for androgen deficiency in aging males.

Authors:  J E Morley; E Charlton; P Patrick; F E Kaiser; P Cadeau; D McCready; H M Perry
Journal:  Metabolism       Date:  2000-09       Impact factor: 8.694

8.  Comparison of the skin irritation potential of two testosterone transdermal systems: an investigational system and a marketed product.

Authors:  W P Jordan; L E Atkinson; C Lai
Journal:  Clin Ther       Date:  1998 Jan-Feb       Impact factor: 3.393

9.  Psychosexual behavior in hypopituitary men: a controlled comparison of gonadotropin and testosterone replacement.

Authors:  R R Clopper; M L Voorhess; M H MacGillivray; P A Lee; B Mills
Journal:  Psychoneuroendocrinology       Date:  1993       Impact factor: 4.905

10.  Prevalence of hypothalamic-pituitary imaging abnormalities in impotent men with secondary hypogonadism.

Authors:  J T Citron; B Ettinger; H Rubinoff; V M Ettinger; J Minkoff; F Hom; P Kan; R Alloo
Journal:  J Urol       Date:  1996-02       Impact factor: 7.450

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  11 in total

Review 1.  Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline.

Authors:  Alvaro Morales; Richard A Bebb; Priya Manjoo; Peter Assimakopoulos; John Axler; Christine Collier; Stacy Elliott; Larry Goldenberg; Irv Gottesman; Ethan D Grober; Gordon H Guyatt; Daniel T Holmes; Jay C Lee
Journal:  CMAJ       Date:  2015-10-26       Impact factor: 8.262

Review 2.  Androgens are fundamental in the maintenance of male sexual health.

Authors:  Alvaro Morales
Journal:  Curr Urol Rep       Date:  2011-12       Impact factor: 3.092

3.  2015 CUA Practice guidelines for erectile dysfunction.

Authors:  Anthony J Bella; Jay C Lee; Serge Carrier; Francois Bénard; Gerald B Brock
Journal:  Can Urol Assoc J       Date:  2015 Jan-Feb       Impact factor: 1.862

Review 4.  Predicting low testosterone in aging men: a systematic review.

Authors:  Adam C Millar; Adrian N C Lau; George Tomlinson; Alan Kraguljac; David L Simel; Allan S Detsky; Lorraine L Lipscombe
Journal:  CMAJ       Date:  2016-06-20       Impact factor: 8.262

Review 5.  Update on Testosterone Replacement Therapy in Hypogonadal Men.

Authors:  Kevin Matthew Yen Bing Leung; Khalid Alrabeeah; Serge Carrier
Journal:  Curr Urol Rep       Date:  2015-08       Impact factor: 3.092

Review 6.  Testosterone deficiency, insulin-resistant obesity and cognitive function.

Authors:  Hiranya Pintana; Nipon Chattipakorn; Siriporn Chattipakorn
Journal:  Metab Brain Dis       Date:  2015-02-24       Impact factor: 3.584

7.  Population-based patterns of prescription androgen use, 1976-2008.

Authors:  Susan A Hall; Gayatri Ranganathan; Liane J Tinsley; Jennifer L Lund; Varant Kupelian; Gary A Wittert; Philip W Kantoff; Alvaro Morales; Andre B Araujo
Journal:  Pharmacoepidemiol Drug Saf       Date:  2014-02-07       Impact factor: 2.890

8.  Quantitative characterization of UDP-glucuronosyltransferase 2B17 in human liver and intestine and its role in testosterone first-pass metabolism.

Authors:  Haeyoung Zhang; Abdul Basit; Diana Busch; King Yabut; Deepak Kumar Bhatt; Marek Drozdzik; Marek Ostrowski; Albert Li; Carol Collins; Stefan Oswald; Bhagwat Prasad
Journal:  Biochem Pharmacol       Date:  2018-08-04       Impact factor: 5.858

9.  Hypoxia reduces testosterone synthesis in mouse Leydig cells by inhibiting NRF1-activated StAR expression.

Authors:  Xueting Wang; Longlu Pan; Zhiran Zou; Dan Wang; Yapeng Lu; Zhangji Dong; Li Zhu
Journal:  Oncotarget       Date:  2017-03-07

10.  Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells.

Authors:  Fengyi Gao; Guoping Li; Chao Liu; Hui Gao; Hao Wang; Weixiao Liu; Min Chen; Yongliang Shang; Lina Wang; Jian Shi; Wenlong Xia; Jianwei Jiao; Fei Gao; Jian Li; Liang Chen; Wei Li
Journal:  J Cell Biol       Date:  2018-04-04       Impact factor: 10.539

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