BACKGROUND: To explore the influence of ovarian cancer histotype on the effectiveness of adjuvant radiotherapy (RT). METHODS: A review of a population-based experience included all referred women with no reported macroscopic residuum following primary surgery who underwent adjuvant platin-based chemotherapy (CT), with or without sequential RT, and for whom it was possible to assign histotype according to the contemporary criteria. RESULTS: Seven hundred and three subjects were eligible, of these 351 received RT. For those with apparent stage I and II tumors, the cohort with clear cell (C), endometrioid (E), and mucinous (M) disease who additionally received RT exhibited a 40% reduction in disease-specific mortality and a 43% reduction in overall mortality. CONCLUSIONS: The curability of those with stage I and II C-, E-, and M-type ovarian carcinomas was enhanced by RT-containing adjuvant therapy. This benefit did not extend to those with stage III or serous tumors. These findings necessitate reassessments of the role of RT and of the nonselective surgical and CT approaches that have characterized ovarian cancer care.
BACKGROUND: To explore the influence of ovarian cancer histotype on the effectiveness of adjuvant radiotherapy (RT). METHODS: A review of a population-based experience included all referred women with no reported macroscopic residuum following primary surgery who underwent adjuvant platin-based chemotherapy (CT), with or without sequential RT, and for whom it was possible to assign histotype according to the contemporary criteria. RESULTS: Seven hundred and three subjects were eligible, of these 351 received RT. For those with apparent stage I and II tumors, the cohort with clear cell (C), endometrioid (E), and mucinous (M) disease who additionally received RT exhibited a 40% reduction in disease-specific mortality and a 43% reduction in overall mortality. CONCLUSIONS: The curability of those with stage I and II C-, E-, and M-type ovarian carcinomas was enhanced by RT-containing adjuvant therapy. This benefit did not extend to those with stage III or serous tumors. These findings necessitate reassessments of the role of RT and of the nonselective surgical and CT approaches that have characterized ovarian cancer care.
Authors: P.J. Hoskins; K.D. Swenerton; M. Manji; F. Wong; S.E. O'Reilly; E.J. McMurtrie; N. Le; B. Acker; J. Le Richer Journal: Int J Gynecol Cancer Date: 1994-07 Impact factor: 3.437
Authors: A F Leary; M Quinn; K Fujiwara; R L Coleman; E Kohn; T Sugiyama; R Glasspool; I Ray-Coquard; N Colombo; M Bacon; A Zeimet; A Westermann; E Gomez-Garcia; D Provencher; S Welch; W Small; D Millan; A Okamoto; G Stuart; K Ochiai Journal: Ann Oncol Date: 2017-04-01 Impact factor: 32.976
Authors: Michael S Anglesio; Kimberly C Wiegand; Nataliya Melnyk; Christine Chow; Clara Salamanca; Leah M Prentice; Janine Senz; Winnie Yang; Monique A Spillman; Dawn R Cochrane; Karey Shumansky; Sohrab P Shah; Steve E Kalloger; David G Huntsman Journal: PLoS One Date: 2013-09-04 Impact factor: 3.240
Authors: Peter F Rambau; Robert A Vierkant; Maria P Intermaggio; Linda E Kelemen; Marc T Goodman; Esther Herpel; Paul D Pharoah; Stefan Kommoss; Mercedes Jimenez-Linan; Beth Y Karlan; Aleksandra Gentry-Maharaj; Usha Menon; Susanna Hernando Polo; Francisco J Candido Dos Reis; Jennifer Anne Doherty; Simon A Gayther; Raghwa Sharma; Melissa C Larson; Paul R Harnett; Emma Hatfield; Jurandyr M de Andrade; Gregg S Nelson; Helen Steed; Joellen M Schildkraut; Micheal E Carney; Estrid Høgdall; Alice S Whittemore; Martin Widschwendter; Catherine J Kennedy; Frances Wang; Qin Wang; Chen Wang; Sebastian M Armasu; Frances Daley; Penny Coulson; Micheal E Jones; Micheal S Anglesio; Christine Chow; Anna de Fazio; Montserrat García-Closas; Sara Y Brucker; Cezary Cybulski; Holly R Harris; Andreas D Hartkopf; Tomasz Huzarski; Allan Jensen; Jan Lubiński; Oleg Oszurek; Javier Benitez; Fady Mina; Annette Staebler; Florin Andrei Taran; Jana Pasternak; Aline Talhouk; Mary Anne Rossing; Joy Hendley; Robert P Edwards; Sian Fereday; Francesmary Modugno; Roberta B Ness; Weiva Sieh; Mona A El-Bahrawy; Stacey J Winham; Jenny Lester; Susanne K Kjaer; Jacek Gronwald; Peter Sinn; Peter A Fasching; Jenny Chang-Claude; Kirsten B Moysich; David D Bowtell; Brenda Y Hernandez; Hugh Luk; Sabine Behrens; Mitul Shah; Audrey Jung; Prafull Ghatage; Jennifer Alsop; Kathryn Alsop; Jesús García-Donas; Pamela J Thompson; Anthony J Swerdlow; Chloe Karpinskyj; Alicia Cazorla-Jiménez; María J García; Susha Deen; Lynne R Wilkens; José Palacios; Andrew Berchuck; Jennifer M Koziak; James D Brenton; Linda S Cook; Ellen L Goode; David G Huntsman; Susan J Ramus; Martin Köbel Journal: J Pathol Clin Res Date: 2018-09-21