Literature DB >> 20692701

Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system.

Hiroyasu Takemoto1, Atsushi Ishii, Kanjiro Miyata, Masataka Nakanishi, Makoto Oba, Takehiko Ishii, Yuichi Yamasaki, Nobuhiro Nishiyama, Kazunori Kataoka.   

Abstract

An siRNA-grafted polymer through disulfide linkage was prepared to improve the physicochemical properties and transfection efficacies of the polyion complexes (PICs) as a nanocarrier of siRNA. The siRNA-grafted polymer formed stable PICs due to its larger numbers and higher density of anionic charges compared with monomeric siRNA, leading to effective internalization by cultured cells. Following the endosomal escape of the PIC, the disulfide linkage of the siRNA-grafted polymer allowed efficient siRNA release from the PIC under intracellular reductive conditions. Consequently, the PIC from the siRNA-grafted polymer showed a potent gene silencing effect without cytotoxicity or immunogenicity, demonstrating a promising feature of the siRNA-grafted polymer to construct the PIC-based nanocarrier for in vivo siRNA delivery. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20692701     DOI： 10.1016/j.biomaterials.2010.07.015

Source DB:  PubMed          Journal:  Biomaterials        ISSN： 0142-9612            Impact factor:   12.479


  12 in total

Review 1.  Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release.

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2.  Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier.

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Journal:  Biomaterials       Date:  2010-10-20       Impact factor: 12.479

Review 3.  Stimuli-responsive nanocarriers for drug delivery.

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Journal:  Nat Mater       Date:  2013-11       Impact factor: 43.841

Review 4.  Strategies, design, and chemistry in siRNA delivery systems.

Authors:  Yizhou Dong; Daniel J Siegwart; Daniel G Anderson
Journal:  Adv Drug Deliv Rev       Date:  2019-05-15       Impact factor: 15.470

Review 5.  New short interfering RNA-based therapies for glomerulonephritis.

Authors:  Hideki Shimizu; Toshiro Fujita
Journal:  Nat Rev Nephrol       Date:  2011-05-24       Impact factor: 28.314

Review 6.  Bulk and nanoscale polypeptide based polyelectrolyte complexes.

Authors:  Amanda B Marciel; Eun Ji Chung; Blair K Brettmann; Lorraine Leon
Journal:  Adv Colloid Interface Sci       Date:  2016-07-02       Impact factor: 12.984

7.  Mechanistic Nanotherapeutic Approach Based on siRNA-Mediated DJ-1 Protein Suppression for Platinum-Resistant Ovarian Cancer.

Authors:  Canan Schumann; Stephanie Chan; Oleh Khalimonchuk; Shannon Khal; Vitaliya Moskal; Vidhi Shah; Adam W G Alani; Olena Taratula; Oleh Taratula
Journal:  Mol Pharm       Date:  2016-05-26       Impact factor: 4.939

8.  Endosomal escape and siRNA delivery with cationic shell crosslinked knedel-like nanoparticles with tunable buffering capacities.

Authors:  Ritu Shrestha; Mahmoud Elsabahy; Stephanie Florez-Malaver; Sandani Samarajeewa; Karen L Wooley
Journal:  Biomaterials       Date:  2012-08-16       Impact factor: 12.479

9.  Development of cholesteryl peptide micelles for siRNA delivery.

Authors:  Bin Qin; Zhijin Chen; Wei Jin; Kun Cheng
Journal:  J Control Release       Date:  2013-08-19       Impact factor: 9.776

10.  In vivo site-specific transfection of naked plasmid DNA and siRNAs in mice by using a tissue suction device.

Authors:  Kazunori Shimizu; Shigeru Kawakami; Kouji Hayashi; Hideyuki Kinoshita; Koichiro Kuwahara; Kazuwa Nakao; Mitsuru Hashida; Satoshi Konishi
Journal:  PLoS One       Date:  2012-07-23       Impact factor: 3.240
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