Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Signal transduction: RABGEF1 fingers RAS for ubiquitination.

Literature DB >> 20692608

Signal transduction: RABGEF1 fingers RAS for ubiquitination.

Abstract

RAS proteins conduct signaling from surface receptors to cytoplasmic effectors, and RAS gain-of-function mutations are pervasive in cancer. A new mechanism for RAS signal attenuation with implications for receptor trafficking has been uncovered. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20692608 PMCID： PMC2950067 DOI： 10.1016/j.cub.2010.06.019

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

20 in total

1. RabGEF1 is a negative regulator of mast cell activation and skin inflammation.

Authors: See-Ying Tam; Mindy Tsai; John N Snouwaert; Janet Kalesnikoff; Didier Scherrer; Susumu Nakae; Devavani Chatterjea; Donna M Bouley; Stephen J Galli
Journal: Nat Immunol Date: 2004-07-04 Impact factor: 25.606

2. Protein binding and signaling properties of RIN1 suggest a unique effector function.

Authors: L Han; D Wong; A Dhaka; D Afar; M White; W Xie; H Herschman; O Witte; J Colicelli
Journal: Proc Natl Acad Sci U S A Date: 1997-05-13 Impact factor: 11.205

3. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.

Authors: Hailiang Hu; Joanne M Bliss; Ying Wang; John Colicelli
Journal: Curr Biol Date: 2005-05-10 Impact factor: 10.834

4. Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.

Authors: Hua Yan; Maryam Jahanshahi; Elizabeth A Horvath; Hsiu-Yu Liu; Cathie M Pfleger
Journal: Curr Biol Date: 2010-07-22 Impact factor: 10.834

5. Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination.

Authors: Lizhong Xu; Veronica Lubkov; Laura J Taylor; Dafna Bar-Sagi
Journal: Curr Biol Date: 2010-07-22 Impact factor: 10.834

6. Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex.

Authors: R Lippé; M Miaczynska; V Rybin; A Runge; M Zerial
Journal: Mol Biol Cell Date: 2001-07 Impact factor: 4.138

7. Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

Authors: G G Tall; M A Barbieri; P D Stahl; B F Horazdovsky
Journal: Dev Cell Date: 2001-07 Impact factor: 12.270

8. The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis.

Authors: M Alejandro Barbieri; Chen Kong; Pin-I Chen; Bruce F Horazdovsky; Philip D Stahl
Journal: J Biol Chem Date: 2003-06-03 Impact factor: 5.157

Signal transduction: RABGEF1 fingers RAS for ubiquitination.

1. RabGEF1 is a negative regulator of mast cell activation and skin inflammation.

2. Protein binding and signaling properties of RIN1 suggest a unique effector function.

3. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.

4. Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.

5. Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination.

6. Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex.

7. Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

8. The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis.

Review 9. Human RAS superfamily proteins and related GTPases.

10. A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1.

1. Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination.

Review 2. Ubiquitin on ras: warden or partner in crime?

Review 3. Versatile roles of k63-linked ubiquitin chains in trafficking.

4. MARCH6 promotes hepatocellular carcinoma development through up-regulation of ATF2.

5. Drug Target Exploitable Structural Features of Adenylyl Cyclase Activity in Schistosoma mansoni.