| Literature DB >> 20692280 |
Tina Ly1, Neeru Gupta, Robert N Weinreb, Paul L Kaufman, Yeni H Yücel.
Abstract
Neural degeneration in glaucoma involves retinal ganglion cells and neurons of their major target, the lateral geniculate nucleus (LGN). Dendrites of relay LGN neurons projecting to the visual cortex were studied by immunocytochemical and quantitative Sholl analysis in combination with confocal microscopy and 3D-morphometry. In non-human adult primate glaucoma, relay LGN neurons showed reduced dendrite complexity and length, and these changes were modified by NMDA receptor blockade. Dendrite plasticity of LGN relay neurons in adult primate glaucoma has implications for potential disease modification by treatment interventions.Entities:
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Year: 2010 PMID: 20692280 PMCID: PMC3125971 DOI: 10.1016/j.visres.2010.08.003
Source DB: PubMed Journal: Vision Res ISSN: 0042-6989 Impact factor: 1.886