Literature DB >> 20692280

Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma.

Tina Ly1, Neeru Gupta, Robert N Weinreb, Paul L Kaufman, Yeni H Yücel.   

Abstract

Neural degeneration in glaucoma involves retinal ganglion cells and neurons of their major target, the lateral geniculate nucleus (LGN). Dendrites of relay LGN neurons projecting to the visual cortex were studied by immunocytochemical and quantitative Sholl analysis in combination with confocal microscopy and 3D-morphometry. In non-human adult primate glaucoma, relay LGN neurons showed reduced dendrite complexity and length, and these changes were modified by NMDA receptor blockade. Dendrite plasticity of LGN relay neurons in adult primate glaucoma has implications for potential disease modification by treatment interventions.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 20692280      PMCID: PMC3125971          DOI: 10.1016/j.visres.2010.08.003

Source DB:  PubMed          Journal:  Vision Res        ISSN: 0042-6989            Impact factor:   1.886


  42 in total

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