Literature DB >> 20691893

Fyn-tau-amyloid: a toxic triad.

Christian Haass1, Eckhard Mandelkow.   

Abstract

The axonal protein tau and amyloid beta-peptide (Abeta) are key players in the pathogenesis of Alzheimer's disease, and tau mediates Abeta toxicity, but it is not clear how. Ittner et al. (2010) now report an unexpected physiological function for tau in neuronal dendrites that may explain how tau mediates Abeta toxicity. Copyright 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 20691893     DOI： 10.1016/j.cell.2010.07.032

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  36 in total

1.  Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases.

Authors:  Nicolas G Bazan; Miguel F Molina; William C Gordon
Journal:  Annu Rev Nutr       Date:  2011-08-21       Impact factor: 11.848

2.  Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

Authors:  Erik D Roberson; Brian Halabisky; Jong W Yoo; Jinghua Yao; Jeannie Chin; Fengrong Yan; Tiffany Wu; Patricia Hamto; Nino Devidze; Gui-Qiu Yu; Jorge J Palop; Jeffrey L Noebels; Lennart Mucke
Journal:  J Neurosci       Date:  2011-01-12       Impact factor: 6.167

Review 3.  Three dimensions of the amyloid hypothesis: time, space and 'wingmen'.

Authors:  Erik S Musiek; David M Holtzman
Journal:  Nat Neurosci       Date:  2015-06       Impact factor: 24.884

4.  Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles.

Authors:  P Joshi; E Turola; A Ruiz; A Bergami; D D Libera; L Benussi; P Giussani; G Magnani; G Comi; G Legname; R Ghidoni; R Furlan; M Matteoli; C Verderio
Journal:  Cell Death Differ       Date:  2013-12-13       Impact factor: 15.828

5.  Inducible Expression of a Truncated Form of Tau in Oligodendrocytes Elicits Gait Abnormalities and a Decrease in Myelin: Implications for Selective CNS Degenerative Diseases.

Authors:  Patrizia LoPresti
Journal:  Neurochem Res       Date:  2015-09-22       Impact factor: 3.996

6.  Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.

Authors:  Guy R Watkins; Ning Wang; Matthew D Mazalouskas; Rey J Gomez; Chris R Guthrie; Brian C Kraemer; Susann Schweiger; Benjamin W Spiller; Brian E Wadzinski
Journal:  J Biol Chem       Date:  2012-05-21       Impact factor: 5.157

7.  Nicotinic Acetylcholine Receptors Sensitize a MAPK-linked Toxicity Pathway on Prolonged Exposure to β-Amyloid.

Authors:  Komal Arora; Justin Cheng; Robert A Nichols
Journal:  J Biol Chem       Date:  2015-07-02       Impact factor: 5.157

8.  Alzheimer's Disease and Protein Kinases.

Authors:  Ayse Basak Engin; Atilla Engin
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 9.  Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement.

Authors:  Erik S Musiek; David M Holtzman
Journal:  Curr Opin Neurol       Date:  2012-12       Impact factor: 5.710

10.  The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease.

Authors:  Megan Larson; Mathew A Sherman; Fatou Amar; Mario Nuvolone; Julie A Schneider; David A Bennett; Adriano Aguzzi; Sylvain E Lesné
Journal:  J Neurosci       Date:  2012-11-21       Impact factor: 6.167
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