| Literature DB >> 20691487 |
Bhanu Chandra Mulukutla1, Salmaan Khan, Alex Lange, Wei-Shou Hu.
Abstract
Cultured mammalian cells are major vehicles for producing therapeutic proteins, and energy metabolism in those cells profoundly affects process productivity. The characteristic high glucose consumption and lactate production of industrial cell lines as well as their adverse effects on productivity have been the target of both cell line and process improvement for several decades. Recent research advances have shed new light on regulation of glucose metabolism and its links to cell proliferation. This review highlights our current understanding in this area of crucial importance in bioprocessing and further discusses strategies for harnessing new findings toward process enhancement through the manipulation of cellular energy metabolism. Copyright 2010. Published by Elsevier Ltd.Entities:
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Year: 2010 PMID： 20691487 DOI： 10.1016/j.tibtech.2010.06.005
Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536