Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus.

Literature DB >> 20691456

An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus.

Noriko Handa¹, Takeshi Yamada, Reiko Tanaka.

Abstract

An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol (1), and two lanostane-type triterpenoids, inonotsudiol A (2) and inonotsuoxodiol A (3), were isolated from the sclerotia of Inonotus obliquus. Their structures were determined to be (3S,7S,9R)-3,7-dihydroxy-7(8-->9)abeo-lanost-24-en-8-one (1), lanosta-8,24-dien-3beta,11beta-diol (2), and (22R)-3beta,22-dihydroxylanosta-8,24-dien-11-one (3) on the basis of NMR spectroscopy, including 1D and 2D ((1)H-(1)H COSY, NOESY, HMQC, HMBC) NMR, and FABMS. Compounds 1-3 showed moderate activity against cultured P388, L1210, HL-60 and KB cells.

Entities: Chemical Species

Mesh：

Substances：

Year: 2010 PMID： 20691456 DOI： 10.1016/j.phytochem.2010.07.005

Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072

Keyword Cloud
Cited

5 in total

An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus.

1. Chemical constituents from Inonotus obliquus and their antitumor activities.

2. A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction.

3. Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone.

4. Actions of Inonotus obliquus against Hyperuricemia through XOD and Bioactives Screened by Molecular Modeling.

Review 5. Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy.