Literature DB >> 2069095

Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac.

R Melarange1, C Gentry, C O'Connell, P R Blower.   

Abstract

Repeat oral dosing of nabumetone for 1 month maintains anti-inflammatory efficacy in a carrageenan model of paw oedema yet does not cause gastrointestinal damage. In contrast, ibuprofen or diclofenac, while also retaining anti-inflammatory activity, produced marked gastrointestinal irritancy as evidenced by mucosal damage and blood loss.

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Year:  1991        PMID： 2069095     DOI： 10.1007/978-3-0348-7405-2_3

Source DB:  PubMed          Journal:  Agents Actions Suppl        ISSN： 0379-0363


  3 in total

1.  Effects of chronic treatment with indomethacin at clinically relevant doses on intestinal tissue 6-keto prostaglandin F1 alpha and leukotriene B4 level in relation to gastroenteropathy.

Authors:  A Uçar; S D Sak; M Melli
Journal:  Inflammation       Date:  1998-06       Impact factor: 4.092

2.  Gastrointestinal irritancy, antiinflammatory activity, and prostanoid inhibition in the rat. Differentiation of effects between nabumetone and etodolac.

Authors:  R Melarange; C Gentry; M Durie; C O'Connell; P R Blower
Journal:  Dig Dis Sci       Date:  1994-03       Impact factor: 3.199

3.  The Anti-Inflammatory Effect of a γ-Lactone Isolated from Ostrich Oil of Struthio camelus (Ratite) and Its Formulated Nano-Emulsion in Formalin-Induced Paw Edema.

Authors:  Salah E M Eltom; Ahmed A H Abdellatif; Hamzah Maswadeh; Mohsen S Al-Omar; Atef A Abdel-Hafez; Hamdoon A Mohammed; Eiman Me Agabein; Ibrahim Alqasoomi; Salem A Alrashidi; Mohammed S M Sajid; Mugahid A Mobark
Journal:  Molecules       Date:  2021-06-17       Impact factor: 4.411
  3 in total

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