Literature DB >> 20690800

Manganese superoxide dismutase expression as a function of genotype and lung cancer pathology.

Robert C G Martin1, Yan Li, Qiahong Liu, David F Barker, Mark A Doll, David W Hein.   

Abstract

INTRODUCTION: The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue.
METHODS: One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression.
RESULTS: The median normal MnSOD expression was 42% with a range of 10 to 70%, which was significantly greater (p = .001) than the median MnSOD expression in the tumor samples that was 18.8% and ranged from 1.1 to 50%.
CONCLUSION: MnSOD expression is significantly reduced in lung adenocarcinoma and squamous cell carcinoma compared to the matched normal lung tissue.

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Year:  2010        PMID： 20690800      PMCID： PMC3196322          DOI： 10.3109/07357900903405918

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  22 in total

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