Amino acid metabolism in helminths.

Amino acids are major constituents of biological material. Chemically they are extremely stable and combine a relatively simple molecular structure with a wide range of properties and functions. In general, amino acid metabolism in helminths has been relatively neglected and the information available is often uneven and of uncertain quality. However, the search for new target sites for anthelmintic development has led to a renewed interest in this area. The amino acid composition of helminths is similar to that of other invertebrates and no unique amino acids have been reported. With the possible addition of tyrosine, helminths seem to require the same 10 essential amino acids as mammals and, where studied in detail, the pathways of amino acid synthesis in helminths are similar to those of mammals. Although amino acids are not a significant energy source in parasites, helminths are able to catabolize amino acids by pathways which, again, appear identical to those found in mammals. Helminths have also been shown to carry out a number of oxidative reactions associated with amino acid metabolism, including cysteine dioxygenase, proline hydroxylase and tryptophan hydroxylase. There are, however, differences in detail between the pathways of amino acid metabolism in helminths and mammals, particularly in the metabolism of the sulphur amino acids and arginine and proline. These differences may be exploitable in anthelmintic design and proline analogues and proline biosynthesis inhibitors show some potential as fasciolicides (Sheers et al., 1982). Differences in metabolism between parasites and their hosts may be the result of parasitic adaptation or they may merely reflect general features of the invertebrate phyla as a whole. Thus a comparison of amino acid metabolism in parasitic helminths with that of their free-living relatives may give some insight into the biochemical basis of parasitism.