Literature DB >> 2068966

Distribution of mouse interferon-beta in normal and brain tumour-bearing mice.

Y Mihara1, J Kuratsu, S Takaki, K Hori, E Nagai, Y Satoh, N Minowa, Y Ushio.   

Abstract

The distribution of 125I-labelled recombinant mouse interferon-beta (rMuIFN-beta) in normal and glioma (203 glioma) bearing mice was studied by radioassay and macro-autoradiography at 15 and 30 min after a single intravenous injection. The level of rMuIFN-beta in the spleen was about 20-fold higher than in serum. Concentrations higher than the serum level was detected in the lung, liver and kidney. The concentration of rMuIFN-beta in the brain was 8% of the serum level and the concentration in the glioma 30 min after administration was about 10-fold higher than in normal mouse brain. Macro-autoradiographic study demonstrated a wide distribution range and selective uptake in glioma tissue. Furthermore, we found that mouse gliomas were sensitive to mouse IFN-beta. Our findings demonstrate that in the mouse glioma model, intravenously administered interferon reaches the tumour.

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Year:  1991        PMID： 2068966     DOI： 10.1007/BF01405697

Source DB:  PubMed          Journal:  Acta Neurochir (Wien)        ISSN： 0001-6268            Impact factor:   2.216


  36 in total

1.  Interferon crosses blood-cerebrospinal fluid barrier in monkeys.

Authors:  D V Habif; R Lipton; K Cantell
Journal:  Proc Soc Exp Biol Med       Date:  1975-05

2.  KINETICS OF MOVEMENT OF IODIDE, SUCROSE, INULIN AND RADIO-IODINATED SERUM ALBUMIN IN THE CENTRAL NERVOUS SYSTEM AND CEREBROSPINAL FLUID OF THE RAT.

Authors:  D J REED; D M WOODBURY
Journal:  J Physiol       Date:  1963-12       Impact factor: 5.182

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Journal:  Acta Radiol Suppl       Date:  1954

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Authors:  M C Alley; D A Scudiero; A Monks; M L Hursey; M J Czerwinski; D L Fine; B J Abbott; J G Mayo; R H Shoemaker; M R Boyd
Journal:  Cancer Res       Date:  1988-02-01       Impact factor: 12.701

5.  Protein iodination with solid state lactoperoxidase.

Authors:  G S David; R A Reisfeld
Journal:  Biochemistry       Date:  1974-02-26       Impact factor: 3.162

6.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

7.  The uptake, distribution, and antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the murine glioma.

Authors:  V A Levin; W R Shapiro; T P Clancy; V T Oliverio
Journal:  Cancer Res       Date:  1970-10       Impact factor: 12.701

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Authors:  V A Levin; M Freeman-Dove; H D Landahl
Journal:  Arch Neurol       Date:  1975-12

9.  Production of recombinant mouse beta-interferon.

Authors:  T Tanaka; M Naruto; G Kawano
Journal:  J Interferon Res       Date:  1986-08

10.  Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines.

Authors:  D A Scudiero; R H Shoemaker; K D Paull; A Monks; S Tierney; T H Nofziger; M J Currens; D Seniff; M R Boyd
Journal:  Cancer Res       Date:  1988-09-01       Impact factor: 12.701
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  1 in total

1.  Pharmacokinetics, pharmacodynamics, and safety of peginterferon beta-1a in subjects with normal or impaired renal function.

Authors:  Xiao Hu; Ali Seddighzadeh; Scott Stecher; Ying Zhu; Jaya Goyal; Mark Matson; Thomas Marbury; William Smith; Ivan Nestorov; Serena Hung
Journal:  J Clin Pharmacol       Date:  2014-09-23       Impact factor: 3.126
  1 in total

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