BACKGROUND: Mannose-binding lectin (MBL) deficiency is associated with susceptibility to respiratory infections. We investigated the impact of MBL2 gene polymorphisms and MBL deficiency on the recurrence of infective exacerbation in patients with COPD. METHODS: A prospective study was conducted among 215 patients with COPD and 137 healthy subjects. MBL deficiency was determined by the MBL2 gene polymorphisms and serum levels of MBL. RESULTS: The average frequency of infective exacerbations over 3 years in the 215 patients with COPD was 2.5 ± 1.3 episodes. The COPD group with three or more episodes of infective exacerbation (recurrent exacerbators) included 96 patients, and the remaining 119 patients had two or fewer episodes (less-frequent exacerbators). Among the 96 recurrent exacerbators, 12 (12.50%) had the MBL deficiency genotype compared with 5 (4.20%) among the less-frequent exacerbators (OR, 3.25; 95% CI, 1.01-11.07; P = .0253). In recurrent exacerbators, the frequency of infective exacerbation was significantly higher in patients with MBL-deficient genotypes than in those with non-MBL-deficient genotypes (4.75 ± 1.22 vs 3.52 ± 0.78, respectively; P < .0001). In addition, mortality was significantly increased in recurrent exacerbators with MBL-deficient genotypes compared with those with non-MBL-deficient genotypes (66.7% vs 31.0%, respectively; P = .0153). CONCLUSIONS: MBL deficiency due to MBL2 polymorphisms increases the risk of recurrent infective exacerbation and worsens its outcome in patients with COPD.
BACKGROUND:Mannose-binding lectin (MBL) deficiency is associated with susceptibility to respiratory infections. We investigated the impact of MBL2 gene polymorphisms and MBL deficiency on the recurrence of infective exacerbation in patients with COPD. METHODS: A prospective study was conducted among 215 patients with COPD and 137 healthy subjects. MBL deficiency was determined by the MBL2 gene polymorphisms and serum levels of MBL. RESULTS: The average frequency of infective exacerbations over 3 years in the 215 patients with COPD was 2.5 ± 1.3 episodes. The COPD group with three or more episodes of infective exacerbation (recurrent exacerbators) included 96 patients, and the remaining 119 patients had two or fewer episodes (less-frequent exacerbators). Among the 96 recurrent exacerbators, 12 (12.50%) had the MBL deficiency genotype compared with 5 (4.20%) among the less-frequent exacerbators (OR, 3.25; 95% CI, 1.01-11.07; P = .0253). In recurrent exacerbators, the frequency of infective exacerbation was significantly higher in patients with MBL-deficient genotypes than in those with non-MBL-deficient genotypes (4.75 ± 1.22 vs 3.52 ± 0.78, respectively; P < .0001). In addition, mortality was significantly increased in recurrent exacerbators with MBL-deficient genotypes compared with those with non-MBL-deficient genotypes (66.7% vs 31.0%, respectively; P = .0153). CONCLUSIONS:MBL deficiency due to MBL2 polymorphisms increases the risk of recurrent infective exacerbation and worsens its outcome in patients with COPD.
Authors: A Apostolou; T Kerenidi; A Michopoulos; K I Gourgoulianis; M Noutsias; A E Germenis; M Speletas Journal: Herz Date: 2016-12-01 Impact factor: 1.443
Authors: Simona Tabea Huebner; Simona Henny; Stéphanie Giezendanner; Thomas Brack; Martin Brutsche; Prashant Chhajed; Christian Clarenbach; Thomas Dieterle; Adrian Egli; Martin Frey; Ingmar Heijnen; Sarosh Irani; Noriane Andrina Sievi; Robert Thurnheer; Marten Trendelenburg; Malcolm Kohler; Anne Barbara Leuppi-Taegtmeyer; Joerg Daniel Leuppi Journal: Respiration Date: 2021-12-23 Impact factor: 3.966
Authors: Jyotshna Mandal; Bijaya Malla; Rudi Steffensen; Luigi Costa; Adrian Egli; Marten Trendelenburg; Francesco Blasi; Kostantinos Kostikas; Tobias Welte; Antoni Torres; Renaud Louis; Wim Boersma; Branislava Milenkovic; Joachim Aerts; Gernot G U Rohde; Alicia Lacoma; Katharina Rentsch; Michael Roth; Michael Tamm; Daiana Stolz Journal: Respir Res Date: 2015-12-18
Authors: Richard K Albert; John Connett; Jeffrey L Curtis; Fernando J Martinez; Meilan K Han; Stephen C Lazarus; Prescott G Woodruff Journal: Int J Chron Obstruct Pulmon Dis Date: 2012-11-23