PURPOSE: To determine the expected ablation zone size and associated isotherms when using clinically available percutaneous cryoprobes for pulmonary cryoablation in a porcine lung model. MATERIALS AND METHODS: Seven ablations were performed in the lungs of three adult pigs using clinically available 2.4-mm cryoprobes (Endocare, Inc, Irvine, California) and a 10-minute double-freeze protocol. Five 18-gauge thermocouples were positioned at 5-mm increments (ie, 5, 10, 15, 20, and 25 mm) from the cryoprobe. Real-time tissue temperatures were recorded during the cryoablation. The isotherms obtained during the ablation and the pathological ablation zones were measured. RESULTS: The pathologic zone of complete necrosis had a mean diameter of 2.4 + or - 0.2 cm, with a mean area of 4.6 + or - 0.6 cm(2) and a circularity of 0.95 + or - 0.04. In comparison, the mean diameter (+ or - standard deviation) of the 0 degrees C, -20 degrees C, and -40 degrees C isotherms were 3.1 + or - 0.2 cm, 2.3 + or - 0.3 cm, and 1.8 + or - 0.4 cm, respectively. The -20 degrees C isotherm was most closely related to the pathologic zone of ablation. CONCLUSIONS: This study establishes the temperature isotherms and associated ablation zone size that can be expected with modern percutaneous cryoprobes in an in vivo porcine lung model. Copyright 2010 SIR. Published by Elsevier Inc. All rights reserved.
PURPOSE: To determine the expected ablation zone size and associated isotherms when using clinically available percutaneous cryoprobes for pulmonary cryoablation in a porcine lung model. MATERIALS AND METHODS: Seven ablations were performed in the lungs of three adult pigs using clinically available 2.4-mm cryoprobes (Endocare, Inc, Irvine, California) and a 10-minute double-freeze protocol. Five 18-gauge thermocouples were positioned at 5-mm increments (ie, 5, 10, 15, 20, and 25 mm) from the cryoprobe. Real-time tissue temperatures were recorded during the cryoablation. The isotherms obtained during the ablation and the pathological ablation zones were measured. RESULTS: The pathologic zone of complete necrosis had a mean diameter of 2.4 + or - 0.2 cm, with a mean area of 4.6 + or - 0.6 cm(2) and a circularity of 0.95 + or - 0.04. In comparison, the mean diameter (+ or - standard deviation) of the 0 degrees C, -20 degrees C, and -40 degrees C isotherms were 3.1 + or - 0.2 cm, 2.3 + or - 0.3 cm, and 1.8 + or - 0.4 cm, respectively. The -20 degrees C isotherm was most closely related to the pathologic zone of ablation. CONCLUSIONS: This study establishes the temperature isotherms and associated ablation zone size that can be expected with modern percutaneous cryoprobes in an in vivo porcine lung model. Copyright 2010 SIR. Published by Elsevier Inc. All rights reserved.
Authors: J Louis Hinshaw; Lisa Sampson; Fred T Lee; Paul F Laeseke; Christopher L Brace Journal: J Vasc Interv Radiol Date: 2008-07-26 Impact factor: 3.464
Authors: Christophe L Nguyen; Walter J Scott; Nancy A Young; Tina Rader; Lydia R Giles; Melvyn Goldberg Journal: Chest Date: 2005-11 Impact factor: 9.410
Authors: Muneeb Ahmed; Zhengjun Liu; Karim S Afzal; Dawn Weeks; S Melvyn Lobo; Jonathan B Kruskal; Robert E Lenkinski; S Nahum Goldberg Journal: Radiology Date: 2004-03 Impact factor: 11.105