| Literature DB >> 20687485 |
Stuart Hunt1, Jeffrey Green, Peter J Artymiuk.
Abstract
Certain strains of Escherichia coli, Salmonella enterica and Shigella flexneri produce a pore-forming toxin hemolysin E (HlyE), also known as cytolysin A (ClyA) and silent hemolysin, locus A (SheA). HlyE lyses erythrocytes and mammalian cells, forming transmembrane pores with a minimum internal diameter of-25 A. We review the current knowledge of HlyE structure and function in its solution and pore forms, models for membrane insertion, its potential use in biotechnology applications and its relationship to a wider superfamily of toxins.Entities:
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Year: 2010 PMID： 20687485 DOI： 10.1007/978-1-4419-6327-7_10
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622