Literature DB >> 20686476

Antidotes and treatments for chemical warfare/terrorism agents: an evidence-based review.

G C Rodgers1, C T Condurache.   

Abstract

This article reviews the evidence supporting the efficacy of antidotes used or recommended for the potential chemical warfare agents of most concern. Chemical warfare agents considered include cyanide, vesicants, pulmonary irritants such as chlorine and phosgene, and nerve agents. The strength of evidence for most antidotes is weak, highlighting the need for additional research in this area.

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Year:  2010        PMID： 20686476     DOI： 10.1038/clpt.2010.152

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  8 in total

1.  An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness.

Authors:  Eleanor M Summerhill; Gary W Hoyle; Sven-Eric Jordt; Bronwen J Jugg; James G Martin; Sadis Matalon; Steven E Patterson; David J Prezant; Alfred M Sciuto; Erik R Svendsen; Carl W White; Livia A Veress
Journal:  Ann Am Thorac Soc       Date:  2017-06

2.  Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection.

Authors:  Adriano Chan; Jingjing Jiang; Alla Fridman; Ling T Guo; G Diane Shelton; Ming-Tao Liu; Carol Green; Kristofer J Haushalter; Hemal H Patel; Jangwoen Lee; David Yoon; Tanya Burney; David Mukai; Sari B Mahon; Matthew Brenner; Renate B Pilz; Gerry R Boss
Journal:  J Med Chem       Date:  2015-02-16       Impact factor: 7.446

3.  In Vitro Characterization of a Threonine-Ligated Molybdenyl-Sulfide Cluster as a Putative Cyanide Poisoning Antidote; Intracellular Distribution, Effects on Organic Osmolyte Homeostasis, and Induction of Cell Death.

Authors:  Johanna M Gretarsdottir; Ian H Lambert; Stefan Sturup; Sigridur G Suman
Journal:  ACS Pharmacol Transl Sci       Date:  2022-09-09

Review 4.  Cyanide and the human brain: perspectives from a model of food (cassava) poisoning.

Authors:  Desire D Tshala-Katumbay; Nadege N Ngombe; Daniel Okitundu; Larry David; Shawn K Westaway; Michael J Boivin; Ngoyi D Mumba; Jean-Pierre Banea
Journal:  Ann N Y Acad Sci       Date:  2016-07-23       Impact factor: 5.691

5.  Neglected role of hydrogen sulfide in sulfur mustard poisoning: Keap1 S-sulfhydration and subsequent Nrf2 pathway activation.

Authors:  Wenqi Meng; Zhipeng Pei; Yongwei Feng; Jie Zhao; Yongchun Chen; Wenwen Shi; Qingqiang Xu; Fengwu Lin; Mingxue Sun; Kai Xiao
Journal:  Sci Rep       Date:  2017-08-25       Impact factor: 4.379

6.  Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits.

Authors:  Dinesh G Goswami; Neha Mishra; Rama Kant; Chapla Agarwal; Claire R Croutch; Robert W Enzenauer; Mark J Petrash; Neera Tewari-Singh; Rajesh Agarwal
Journal:  PLoS One       Date:  2021-10-12       Impact factor: 3.240

Review 7.  Ophthalmological aspects of mustard gas poisoning (focus on management).

Authors:  Mehrdad Rafati-Rahimzadeh; Mehravar Rafati-Rahimzadeh; Sohrab Kazemi; Seyedeh Roghieh Jafarian Amiri; Abbas Soleymani; Ali Akbar Moghadamnia
Journal:  Caspian J Intern Med       Date:  2022

8.  Intubation performance using different laryngoscopes while wearing chemical protective equipment: a manikin study.

Authors:  H Schröder; N Zoremba; R Rossaint; K Deusser; C Stoppe; M Coburn; A Rieg; G Schälte
Journal:  BMJ Open       Date:  2016-03-15       Impact factor: 2.692
  8 in total

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