Literature DB >> 20686135

Correlates of apathy in Huntington's disease.

E van Duijn1, N Reedeker, E J Giltay, R A C Roos, R C van der Mast.   

Abstract

The authors aim to study prevalence and clinical correlates of apathy in Huntington's disease. Apathy was defined as an Apathy Scale score > or =14 points in 152 Huntington's disease mutation carriers and 56 noncarriers. Correlates of apathy were analyzed cross-sectionally in mutation carriers using multivariable logistic regression analysis. Forty-nine (32%) Huntington's disease mutation carriers showed apathy compared to none of the noncarriers. After exclusion of 10 depressed patients, apathy was independently associated with male sex, worse global functioning, and higher use of neuroleptics and benzodiazepines.

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Year:  2010        PMID： 20686135     DOI： 10.1176/jnp.2010.22.3.287

Source DB:  PubMed          Journal:  J Neuropsychiatry Clin Neurosci        ISSN： 0895-0172            Impact factor:   2.198


  8 in total

1.  Longitudinal Psychiatric Symptoms in Prodromal Huntington's Disease: A Decade of Data.

Authors:  Eric A Epping; Ji-In Kim; David Craufurd; Thomas M Brashers-Krug; Karen E Anderson; Elizabeth McCusker; Jolene Luther; Jeffrey D Long; Jane S Paulsen
Journal:  Am J Psychiatry       Date:  2015-10-16       Impact factor: 18.112

2.  Characterization of the Huntington intermediate CAG repeat expansion phenotype in PHAROS.

Authors:  Annie Killoran; Kevin M Biglan; Joseph Jankovic; Shirley Eberly; Elise Kayson; David Oakes; Anne B Young; Ira Shoulson
Journal:  Neurology       Date:  2013-04-26       Impact factor: 9.910

3.  Characterization of depression in prodromal Huntington disease in the neurobiological predictors of HD (PREDICT-HD) study.

Authors:  Eric A Epping; James A Mills; Leigh J Beglinger; Jess G Fiedorowicz; David Craufurd; Megan M Smith; Mark Groves; Kelly R Bijanki; Nancy Downing; Janet K Williams; Jeffrey D Long; Jane S Paulsen
Journal:  J Psychiatr Res       Date:  2013-06-19       Impact factor: 4.791

4.  Relationships Among Apathy, Health-Related Quality of Life, and Function in Huntington's Disease.

Authors:  Nora E Fritz; Nicholas R Boileau; Julie C Stout; Rebecca Ready; Joel S Perlmutter; Jane S Paulsen; Kimberly Quaid; Stacey Barton; Michael K McCormack; Susan L Perlman; Noelle E Carlozzi
Journal:  J Neuropsychiatry Clin Neurosci       Date:  2018-03-21       Impact factor: 2.198

5.  Depression in the early stages of Huntington disease.

Authors:  Eric A Epping; Jane S Paulsen
Journal:  Neurodegener Dis Manag       Date:  2011-10-01

6.  Non-motor symptoms in Huntington's disease: a comparative study with Parkinson's disease.

Authors:  Tatiana Aldaz; Pasquale Nigro; Almudena Sánchez-Gómez; Celia Painous; Lluís Planellas; Pilar Santacruz; Ana Cámara; Yaroslau Compta; Francesc Valldeoriola; Maria J Martí; Esteban Muñoz
Journal:  J Neurol       Date:  2019-03-05       Impact factor: 4.849

7.  Multidimensional Apathy: The Utility of the Dimensional Apathy Scale in Huntington's Disease.

Authors:  Kelly J Atkins; Sophie C Andrews; Trevor T-J Chong; Julie C Stout
Journal:  Mov Disord Clin Pract       Date:  2021-02-12

8.  Clinical Management of Neuropsychiatric Symptoms of Huntington Disease: Expert-Based Consensus Guidelines on Agitation, Anxiety, Apathy, Psychosis and Sleep Disorders.

Authors:  Karen E Anderson; Erik van Duijn; David Craufurd; Carolyn Drazinic; Mary Edmondson; Nathan Goodman; Daniel van Kammen; Clement Loy; Josef Priller; LaVonne Veatch Goodman
Journal:  J Huntingtons Dis       Date:  2018
  8 in total

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