Literature DB >> 20685216

Alpha-glucosidase and tyrosinase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones.

M Iqbal Choudhary1, S Adnan Ali Shah, Shamsun-Nahar Khan, Mahmud Tareq Hassan Khan.   

Abstract

Sixteen new and one known metabolites 4-20 were obtained by incubation of tibolone (1) and hydroxytibolones (2 and 3) with various fungi. Their structures were elucidated by means of a homo and heteronuclear 2D NMR and by HREI-MS techniques. The relative stereochemistry was deduced by 2D NOESY experiment. Metabolites of tibolone (1) exhibited significant inhibitory activities against alpha-glucosidase and tyrosinase enzymes. Hydroxylations at C-6, C-10, C-11, C-15 positions and alpha,beta-unsaturation at C-1/C-2, C-4/C-5 showed potent inhibitory activities against these enzymes. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20685216     DOI： 10.1016/j.steroids.2010.05.017

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  10 in total

1.  Synthesis of some potent immunomodulatory and anti-inflammatory metabolites by fungal transformation of anabolic steroid oxymetholone.

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Journal:  Chem Cent J       Date:  2012-12-10       Impact factor: 4.215

2.  Biotransformation of a potent anabolic steroid, mibolerone, with Cunninghamella blakesleeana, C. echinulata, and Macrophomina phaseolina, and biological activity evaluation of its metabolites.

Authors:  Mahwish Siddiqui; Malik Shoaib Ahmad; Atia-Tul- Wahab; Sammer Yousuf; Narjis Fatima; Nimra Naveed Shaikh; Atta-Ur- Rahman; M Iqbal Choudhary
Journal:  PLoS One       Date:  2017-02-24       Impact factor: 3.240

3.  Bio-Catalytic Structural Transformation of Anti-cancer Steroid, Drostanolone Enanthate with Cephalosporium aphidicola and Fusarium lini, and Cytotoxic Potential Evaluation of Its Metabolites against Certain Cancer Cell Lines.

Authors:  M Iqbal Choudhary; Mahwish Siddiqui; Sammer Yousuf; Narjis Fatima; Malik S Ahmad; Hani Choudhry
Journal:  Front Pharmacol       Date:  2017-12-20       Impact factor: 5.810

4.  Triterpenic Acids as Non-Competitive α-Glucosidase Inhibitors from Boswellia elongata with Structure-Activity Relationship: In Vitro and In Silico Studies.

Authors:  Najeeb Ur Rehman; Sobia Ahsan Halim; Mohammed Al-Azri; Majid Khan; Ajmal Khan; Kashif Rafiq; Ahmed Al-Rawahi; Rene Csuk; Ahmed Al-Harrasi
Journal:  Biomolecules       Date:  2020-05-12

5.  Phenoxy pendant isatins as potent α-glucosidase inhibitors: reciprocal carbonyl⋯carbonyl interactions, antiparallel π⋯π stacking driven solid state self-assembly and biological evaluation.

Authors:  Saba Mehreen; Mehwash Zia; Ajmal Khan; Javid Hussain; Saeed Ullah; Muhammad U Anwar; Ahmed Al-Harrasi; Muhammad Moazzam Naseer
Journal:  RSC Adv       Date:  2022-07-21       Impact factor: 4.036

6.  Evaluation of Major Constituents of Medicinally Important Plants for Anti-Inflammatory, Antidiabetic and AGEs Inhibiting Properties: In Vitro and Simulatory Evidence.

Authors:  Abdul Rafey; Adnan Amin; Muhammad Kamran; Muhammad Imran Aziz; Varda Athar; Shah Iram Niaz; Luc Pieters
Journal:  Molecules       Date:  2022-10-09       Impact factor: 4.927

7.  Microbial transformation of anti-cancer steroid exemestane and cytotoxicity of its metabolites against cancer cell lines.

Authors:  Elias Baydoun; Marium Bibi; Muhammad Asif Iqbal; Atia-Tul Wahab; Dina Farran; Colon Smith; Samina A Sattar; Atta-Ur Rahman; M Iqbal Choudhary
Journal:  Chem Cent J       Date:  2013-03-27       Impact factor: 4.215

Review 8.  Microbial-catalyzed biotransformation of multifunctional triterpenoids derived from phytonutrients.

Authors:  Syed Adnan Ali Shah; Huey Ling Tan; Sadia Sultan; Muhammad Afifi Bin Mohd Faridz; Mohamad Azlan Bin Mohd Shah; Sharifah Nurfazilah; Munawar Hussain
Journal:  Int J Mol Sci       Date:  2014-07-07       Impact factor: 5.923

Review 9.  Microbial Biotransformation to Obtain New Antifungals.

Authors:  Luiz F Bianchini; Maria F C Arruda; Sergio R Vieira; Patrícia M S Campelo; Ana M T Grégio; Edvaldo A R Rosa
Journal:  Front Microbiol       Date:  2015-12-24       Impact factor: 5.640

10.  Optimization and Validation of a Microscale In vitro Method to Assess 
α-Glucosidase Inhibition Activity.

Authors:  Graciela Granados-Guzmán; Rocío Castro-Ríos; Noemí Waksman de Torres; Ricardo Salazar-Aranda
Journal:  Curr Anal Chem       Date:  2018-10       Impact factor: 1.892
  10 in total

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