| Literature DB >> 20685119 |
Marc Gerspacher1, Eva Altmann, René Beerli, Thomas Buhl, Ralf Endres, Rainer Gamse, Jacques Kameni-Tcheudji, Michaela Kneissel, Karl Heinz Krawinkler, Martin Missbach, Alfred Schmidt, Klaus Seuwen, Sven Weiler, Leo Widler.
Abstract
A series of novel benzimidazole derivatives has been designed via a scaffold morphing approach based on known calcilytics chemotypes. Subsequent lead optimisation led to the discovery of penta-substituted benzimidazoles that exhibit attractive in vitro and in vivo calcium-sensing receptor (CaSR) inhibitory profiles. In addition, synthesis and structure-activity relationship data are provided. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20685119 DOI： 10.1016/j.bmcl.2010.07.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823