| Literature DB >> 20684991 |
Sami Joha1, Véronique Dauphin, Frédéric Leprêtre, Sélim Corm, Franck E Nicolini, Christophe Roumier, Olivier Nibourel, Nathalie Grardel, Véronique Maguer-Satta, Thierry Idziorek, Martin Figeac, Jean-Luc Laï, Bruno Quesnel, Gabriel Etienne, François Guilhot, Eric Lippert, Claude Preudhomme, Catherine Roche-Lestienne.
Abstract
To ascertain genomic alterations associated with Imatinib resistance in chronic myeloid leukaemia, we performed high resolution genomic analysis of CD34(+) cells from 25 Imatinib (IM) resistant and 11 responders CML patients. Using patients' T-cells as reference, we found significant association between number of acquired cryptic copy number alterations (CNA) and disease phase (p=0.036) or loss of IM response for patients diagnosed in chronic phase (CP) (p=0.04). Recurrent cryptic losses were identified on chromosomes 7, 12 and 13. On chromosome 7, recurrent deletions of the IKZF1 locus were detected, for the first time, in 4 patients in CP.Entities:
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Year: 2010 PMID： 20684991 DOI： 10.1016/j.leukres.2010.07.012
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156