Literature DB >> 20683702

[Undescended testis: aspects of treatment].

I Körner1, H Rübben.   

Abstract

Undescended testis (UDT) is the most frequent congenital malformation affecting 1% of 1-year-old mature birth boys. If untreated UDT leads to progressive histological changes with impaired spermatogenesis and an increasing risk of testicular cancer. For clinical reasons palpable testes should be differentiated from impalpable testes. Spontaneous testicular descent can be expected only before 6 months of age. Subsequently, treatment should start without delay and be finished before the child has reached the age of 1 year. Surgery is the cornerstone of treatment. Inguinal approaches are standard practice for palpable testes, whereas laparoscopy is used in non-palpable testes. Hormonal treatment is ineffective for inducing testicular descent but facilitates germ cell maturation and an improvement in fertility potential. Only early treatment of UDT reduces germ cell loss, improves fertility and reduces the risk of testicular cancer.

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Year:  2010        PMID: 20683702     DOI: 10.1007/s00120-010-2327-3

Source DB:  PubMed          Journal:  Urologe A        ISSN: 0340-2592            Impact factor:   0.639


  19 in total

Review 1.  The Parkes Lecture. Heat and the testis.

Authors:  B P Setchell
Journal:  J Reprod Fertil       Date:  1998-11

Review 2.  Germ cell development in the descended and cryptorchid testis and the effects of hormonal manipulation.

Authors:  C Ong; S Hasthorpe; J M Hutson
Journal:  Pediatr Surg Int       Date:  2005-02-23       Impact factor: 1.827

3.  Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult.

Authors:  L Dunkel; S Taskinen; O Hovatta; J L Tilly; S Wikström
Journal:  J Clin Invest       Date:  1997-11-01       Impact factor: 14.808

4.  Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen data.

Authors:  P A Lee; M T Coughlin
Journal:  Horm Res       Date:  2001

5.  Does treatment with human chorionic gonadotropin induce reversible changes in undescended testes in boys?

Authors:  S Demirbilek; H F Atayurt; N Celik; G Aydin
Journal:  Pediatr Surg Int       Date:  1997       Impact factor: 1.827

6.  Age at surgery for undescended testis and risk of testicular cancer.

Authors:  Andreas Pettersson; Lorenzo Richiardi; Agneta Nordenskjold; Magnus Kaijser; Olof Akre
Journal:  N Engl J Med       Date:  2007-05-03       Impact factor: 91.245

7.  Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism.

Authors:  F Hadziselimovic; B Hoecht
Journal:  Klin Padiatr       Date:  2008-04-09       Impact factor: 1.349

8.  Ultrasonography is unnecessary in evaluating boys with a nonpalpable testis.

Authors:  Jack S Elder
Journal:  Pediatrics       Date:  2002-10       Impact factor: 7.124

9.  Aetiology of testicular cancer: association with congenital abnormalities, age at puberty, infertility, and exercise. United Kingdom Testicular Cancer Study Group.

Authors: 
Journal:  BMJ       Date:  1994-05-28

Review 10.  Management of cryptorchidism in children: guidelines.

Authors:  Christophe Gapany; Peter Frey; Françoise Cachat; Françoise Gudinchet; Patrice Jichlinski; Blaise-Julien Meyrat; Pascal Ramseyer; Gérald Theintz; Bernard Burnand
Journal:  Swiss Med Wkly       Date:  2008-08-23       Impact factor: 2.193

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  4 in total

Review 1.  [Undescended testis: current treatment guidelines].

Authors:  B Haid
Journal:  Urologe A       Date:  2016-01       Impact factor: 0.639

Review 2.  [Cryptorchidism and fertility].

Authors:  I Rübben
Journal:  Urologe A       Date:  2016-07       Impact factor: 0.639

Review 3.  [Circumcision and orchiopexy: management of complications].

Authors:  M Promm; W H Rösch
Journal:  Urologe A       Date:  2014-05       Impact factor: 0.639

Review 4.  The role of laparoscopy in children with groin problems.

Authors:  Himanshu Aggarwal; Barry A Kogan
Journal:  Transl Androl Urol       Date:  2014-12
  4 in total

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