BACKGROUND/ OBJECTIVES:Helicobacter pylori infection and iron and vitamin B(12) deficiencies are widespread in economically disadvantaged populations. There is emerging evidence that H. pylori infection has a negative effect on the absorption of these micronutrients. The aim of this study was to evaluate the effect of H. pylori infection on the efficacy of micronutrient (including iron and vitamin B(12))-fortified foods supplied for 1 year in marginally nourished children. SUBJECTS/ METHODS: In all, 543 Indian children, aged 6-10 years, participated in a double-blind, randomized controlled intervention trial, receiving foods fortified with either high (100% Recommended Dietary Allowances (RDA)) or low (15% RDA) amounts of iron, vitamin B(12) and other micronutrients. The presence of H. pylori infection was diagnosed by the (13)C-labeled urea breath test at 11 months after the start of the intervention. Blood hemoglobin, serum ferritin (SF), total body iron and plasma vitamin B(12) were estimated at baseline and 12 months, and differences between these time points were assessed using an independent t-test. RESULTS: Overall, the prevalence of H. pylori infection in this group of children was 79%. Baseline hemoglobin, SF, body iron and vitamin B(12) concentrations were not associated with H. pylori infection. The response to the intervention (either high or low amounts of iron and vitamin B(12) fortification) in terms of change in iron markers and vitamin B(12) status did not differ between children with and without H. pylori infection. CONCLUSIONS: This study shows that the presence of H. pylori infection did not affect the efficacy of long-term iron and vitamin B(12) fortification in these marginally nourished children.
RCT Entities:
BACKGROUND/ OBJECTIVES:Helicobacter pyloriinfection and iron and vitamin B(12) deficiencies are widespread in economically disadvantaged populations. There is emerging evidence that H. pyloriinfection has a negative effect on the absorption of these micronutrients. The aim of this study was to evaluate the effect of H. pyloriinfection on the efficacy of micronutrient (including iron and vitamin B(12))-fortified foods supplied for 1 year in marginally nourished children. SUBJECTS/ METHODS: In all, 543 Indian children, aged 6-10 years, participated in a double-blind, randomized controlled intervention trial, receiving foods fortified with either high (100% Recommended Dietary Allowances (RDA)) or low (15% RDA) amounts of iron, vitamin B(12) and other micronutrients. The presence of H. pyloriinfection was diagnosed by the (13)C-labeled urea breath test at 11 months after the start of the intervention. Blood hemoglobin, serum ferritin (SF), total body iron and plasma vitamin B(12) were estimated at baseline and 12 months, and differences between these time points were assessed using an independent t-test. RESULTS: Overall, the prevalence of H. pyloriinfection in this group of children was 79%. Baseline hemoglobin, SF, body iron and vitamin B(12) concentrations were not associated with H. pyloriinfection. The response to the intervention (either high or low amounts of iron and vitamin B(12) fortification) in terms of change in iron markers and vitamin B(12) status did not differ between children with and without H. pyloriinfection. CONCLUSIONS: This study shows that the presence of H. pyloriinfection did not affect the efficacy of long-term iron and vitamin B(12) fortification in these marginally nourished children.
Authors: Michael J Boivin; Angelina M Kakooza; Benjamin C Warf; Leslie L Davidson; Elena L Grigorenko Journal: Nature Date: 2015-11-19 Impact factor: 49.962
Authors: Martin N Mwangi; Kamija S Phiri; Abdelhak Abkari; Mory Gbané; Raphaelle Bourdet-Sicard; Véronique Azaïs Braesco; Michael B Zimmermann; Andrew M Prentice Journal: Nutrients Date: 2017-06-05 Impact factor: 5.717
Authors: Eyad Altamimi; Noor Alsharkhat; Afnan AlJawarneh; Moh D Rawhi Abu Hamad; Anas Abu Assi; Sarah Alawneh; Majd Al-Ahmad Journal: Heliyon Date: 2020-07-20