UNLABELLED: The aim of this study was to evaluate the prognostic information of soluble carbonic anhydrase (CA) IX expression in renal cell carcinoma (RCC). PATIENTS AND METHODS: Serum CA IX was analysed in 361 patients. Tumour type, TNM stage, nuclear grade, and RCC-specific survival were assessed. Serum and immunohistochemical expression were compared. RESULTS: Median serum CA IX expression was 141 (range 2-4, 181) pg/ml. Levels were significantly higher in 287 patients with clear cell, compared to 40 papillary (p<0.001) and 22 oncocytoma (p=0.002), but not to 12 chromophobe RCC (p=0.35). Serum CA IX in clear cell RCC was positively correlated to TNM stage (p=0.002). There was a positive trend between serum and immunohistochemical CA IX expression. In a multivariate analysis of clear cell RCC, TNM stage and nuclear grade were independent prognostic factors. CONCLUSION: Serum CA IX was higher in clear cell RCC compared to other RCC types. In clear cell RCC, serum CA IX correlated to TNM stage, but not survival.
UNLABELLED: The aim of this study was to evaluate the prognostic information of soluble carbonic anhydrase (CA) IX expression in renal cell carcinoma (RCC). PATIENTS AND METHODS: Serum CA IX was analysed in 361 patients. Tumour type, TNM stage, nuclear grade, and RCC-specific survival were assessed. Serum and immunohistochemical expression were compared. RESULTS: Median serum CA IX expression was 141 (range 2-4, 181) pg/ml. Levels were significantly higher in 287 patients with clear cell, compared to 40 papillary (p<0.001) and 22 oncocytoma (p=0.002), but not to 12 chromophobe RCC (p=0.35). Serum CA IX in clear cell RCC was positively correlated to TNM stage (p=0.002). There was a positive trend between serum and immunohistochemical CA IX expression. In a multivariate analysis of clear cell RCC, TNM stage and nuclear grade were independent prognostic factors. CONCLUSION: Serum CA IX was higher in clear cell RCC compared to other RCC types. In clear cell RCC, serum CA IX correlated to TNM stage, but not survival.
Authors: Martina Takacova; Maria Bartosova; Lucia Skvarkova; Miriam Zatovicova; Ivana Vidlickova; Lucia Csaderova; Monika Barathova; Jan Breza; Peter Bujdak; Jaromir Pastorek; Jan Breza; Silvia Pastorekova Journal: Oncol Lett Date: 2012-10-26 Impact factor: 2.967
Authors: Tobias C Wind; Michael P Messenger; Douglas Thompson; Peter J Selby; Rosamonde E Banks Journal: Ann Clin Biochem Date: 2011-03-02 Impact factor: 2.057
Authors: S H Sim; M P Messenger; W M Gregory; T C Wind; N S Vasudev; J Cartledge; D Thompson; P J Selby; R E Banks Journal: Br J Cancer Date: 2012-08-23 Impact factor: 7.640
Authors: Fabian Finkelmeier; Özge Canli; Kai-Henrik Peiffer; Dirk Walter; Andrea Tal; Christine Koch; Ursula Pession; Johannes Vermehren; Jörg Trojan; Stefan Zeuzem; Albrecht Piiper; Florian R Greten; Georgios Grammatikos; Oliver Waidmann Journal: PLoS One Date: 2018-07-16 Impact factor: 3.240