BACKGROUND: Calpains (CAPN) are intracellular, non-lysosomal cytoplasmic cysteine endopeptidases and they are expressed ubiquitously. Their endogenous specific inhibitor is calpastatin. When calcium is present, calpastatin and calpain attach to each other, inhibiting the protease. The calpain system plays an important role in many processes including apoptosis, necrosis, ischaemia and exocytosis. The role of calpains in pathogenesis or further tumour progression has been proved in related studies. This study focused on the expression of the enzymes calpain 1, calpain 2 and the inhibitor calpastatin in normal and malignant endometrial tissue. MATERIALS AND METHODS: Immunohistochemical stainings were performed on paraffin slices and staining intensity, percentage of positive cells and international ratio score were evaluated. RESULTS AND CONCLUSION: The endometrial carcinoma showed a higher expression of calpastatin than benign endometrial tissue.
BACKGROUND: Calpains (CAPN) are intracellular, non-lysosomal cytoplasmic cysteine endopeptidases and they are expressed ubiquitously. Their endogenous specific inhibitor is calpastatin. When calcium is present, calpastatin and calpain attach to each other, inhibiting the protease. The calpain system plays an important role in many processes including apoptosis, necrosis, ischaemia and exocytosis. The role of calpains in pathogenesis or further tumour progression has been proved in related studies. This study focused on the expression of the enzymes calpain 1, calpain 2 and the inhibitor calpastatin in normal and malignant endometrial tissue. MATERIALS AND METHODS: Immunohistochemical stainings were performed on paraffin slices and staining intensity, percentage of positive cells and international ratio score were evaluated. RESULTS AND CONCLUSION: The endometrial carcinoma showed a higher expression of calpastatin than benign endometrial tissue.
Authors: David M Gau; Jamie L Lesnock; Brian L Hood; Rohit Bhargava; Mai Sun; Kathleen Darcy; Soumya Luthra; Uma Chandran; Thomas P Conrads; Robert P Edwards; Joseph L Kelley; Thomas C Krivak; Partha Roy Journal: Cell Cycle Date: 2015 Impact factor: 4.534
Authors: Katarzyna Starska; Ewa Forma; Paweł Jóźwiak; Iwona Lewy-Trenda; Marian Danilewicz; Olga Stasikowska-Kanicka; Michał Skóra; Katarzyna Kolary; Jakub Miazga; Anna Krześlak; Magdalena Bryś Journal: Tumour Biol Date: 2016-07-25
Authors: Da Ma; Juan Fang; Ying Liu; Jing-Jing Song; Yan-Qiong Wang; Juan Xia; Bin Cheng; Zhi Wang Journal: Oncol Lett Date: 2017-04-03 Impact factor: 2.967
Authors: Shadia M Al-Bahlani; Ruqaya M Al-Rashdi; Shiyam Kumar; Shadia S Al-Sinawi; Maiya A Al-Bahri; Asem A Shalaby Journal: Biomed Res Int Date: 2017-04-27 Impact factor: 3.411