Literature DB >> 20682363

Investigation of memory B cell responses to hepatitis B surface antigen in health care workers considered as non-responders to vaccination.

J C Valats1, E Tuaillon, N Funakoshi, D Hoa, M C Brabet, K Bolloré, J Ducos, J P Vendrell, P Blanc.   

Abstract

Up to 20% of health care workers are considered as non-responders to hepatitis B vaccination (anti-HBs<10 m UI/ml in serum). We have explored memory B cells differentiated in vitro into anti-HBs antibody-secreting cells (anti-HBs-SCs) by ELISPOT assay. Anti-HBs-SCs were detected in vaccinated responders (n = 11) and non-responders (n = 10) but IgG anti-HBs-SCs were significantly lower in the non-responder group (p<0.001). Low amounts of HBs antibodies were also quantified by ELISA in non-responders' sera. These results indicate that a suboptimal B cell response exists in non-responders to HBV vaccination. This B cell response may mediate a protection against clinically significant breakthrough hepatitis B infection.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20682363     DOI： 10.1016/j.vaccine.2010.07.058

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  11 in total

1.  Memory T cells specific for HBV enumerated by a peptide-based cultured enzyme-linked immunospot assay in healthy HBV-vaccinated subjects.

Authors:  Irene Cassaniti; Sandra A Calarota; Kodjo M G Adzasehoun; Antonella Chiesa; Giuditta Comolli; Maurizio Parea; Fausto Baldanti
Journal:  Hum Vaccin Immunother       Date:  2016-07-08       Impact factor: 3.452

2.  Identification of occult hepatitis B virus (HBV) infection and viral antigens in healthcare workers who presented low to moderate levels of anti-HBs after HBV vaccination.

Authors:  Zohreh Borzooy; Seyed Mohammad Jazayeri; Abbass Mirshafiey; Azam Khamseh; Masoud Karkhaneh Mahmoudie; Pedram Azimzadeh; Babak Geravand; Mohammad Ali Boroumand; Mina Afshar; Vahdat Poortahmasebi; Mostafa Hosseini; Adrian Streinu-Cercel
Journal:  Germs       Date:  2015-12-02

3.  Significant transcriptome and cytokine changes in hepatitis B vaccine non-responders revealed by genome-wide comparative analysis.

Authors:  Shaohui Qiu; Peng He; Xin Fang; Haiqing Tong; Jingjing Lv; Jiaye Liu; Li Zhang; Xiangjun Zhai; Liying Wang; Zhongyu Hu; Yongli Yu
Journal:  Hum Vaccin Immunother       Date:  2018-05-14       Impact factor: 3.452

4.  Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin.

Authors:  Xinwen Lin; Trix Twelkmeyer; Danming Zhu; Li Zhang; Yang Zhao; Chao Zhang; Yoichiro Iwakura; Guangxun Meng; Zhaolin Hua; Bingyu Yan; William J Liu; Zhongguang Luo; Sitang Gong; Hairong Chen; Shuran Li; Baidong Hou; Hong Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2021-04-27       Impact factor: 11.205

5.  HBV vaccination status and response to hepatitis B vaccine among Iranian dentists, correlation with risk factors and preventive measures.

Authors:  Nafiseh Momeni; Mohammad Sadegh Ahmad Akhoundi; Seyed Moayed Alavian; Ahmad Reza Shamshiri; Mehdy Norouzi; Nima Mahboobi; Nilufar Moosavi; Seyed Mohammad Jazayeri
Journal:  Hepat Mon       Date:  2014-12-27       Impact factor: 0.660

6.  Use of ELISpot assay to study HBs-specific B cell responses in vaccinated and HBV infected humans.

Authors:  Chen Tian; Yuxin Chen; Yong Liu; Shixia Wang; Yang Li; Guiyang Wang; Juan Xia; Xiang-An Zhao; Rui Huang; Shan Lu; Chao Wu
Journal:  Emerg Microbes Infect       Date:  2018-02-16       Impact factor: 7.163

Review 7.  Toward a Functional Cure for Hepatitis B: The Rationale and Challenges for Therapeutic Targeting of the B Cell Immune Response.

Authors:  Zhiyong Ma; Ejuan Zhang; Shicheng Gao; Yong Xiong; Mengji Lu
Journal:  Front Immunol       Date:  2019-09-24       Impact factor: 7.561

8.  The relationship between the clearance of HBsAg and the remodeling of B cell subsets in CHB patients treated with Peg-IFN-α.

Authors:  Ze-Qian Wu; Lei Tan; Wei-Qiang Gan; Zhi-Shuo Mo; Da-Biao Chen; Pei-Pei Wang; Qi-Yi Zhao; Dong-Ying Xie; Zhi-Liang Gao
Journal:  Ann Transl Med       Date:  2021-03

9.  HPV-Specific Systemic Antibody Responses and Memory B Cells are Independently Maintained up to 6 Years and in a Vaccine-Specific Manner Following Immunization with Cervarix and Gardasil in Adolescent and Young Adult Women in Vaccination Programs in Italy.

Authors:  Francesco Nicoli; Barbara Mantelli; Eleonora Gallerani; Valentina Telatin; Irene Bonazzi; Peggy Marconi; Riccardo Gavioli; Liliana Gabrielli; Tiziana Lazzarotto; Luisa Barzon; Giorgio Palù; And Antonella Caputo
Journal:  Vaccines (Basel)       Date:  2020-01-14

10.  Hepatitis B Vaccine Non-Responders Show Higher Frequencies of CD24highCD38high Regulatory B Cells and Lower Levels of IL-10 Expression Compared to Responders.

Authors:  Nina Körber; Laureen Pohl; Birgit Weinberger; Beatrix Grubeck-Loebenstein; Andrea Wawer; Percy A Knolle; Hedwig Roggendorf; Ulrike Protzer; Tanja Bauer
Journal:  Front Immunol       Date:  2021-09-10       Impact factor: 7.561
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