Literature DB >> 20681600

Simple and efficient preparation of 2,5-disubstituted oxazoles via a metal-free-catalyzed cascade cyclization.

Changfeng Wan1, Linfeng Gao, Qiang Wang, Jintang Zhang, Zhiyong Wang.   

Abstract

A practical and simple synthesis of 2,5-disubstituted oxazoles was developed via an iodine-catalyzed tandem oxidative cyclization. A wide range of common commercial aromatic aldehydes can be used as reaction substrates, which displayed excellent functional group compatibility in this reaction.

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Year:  2010        PMID： 20681600     DOI： 10.1021/ol101596s

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Oxazoles for click chemistry II: synthesis of extended heterocyclic scaffolds.

Authors:  Pravin C Patil; Frederick A Luzzio; Donald R Demuth
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

2.  Room temperature copper(II)-catalyzed oxidative cyclization of enamides to 2,5-disubstituted oxazoles via vinylic C-H functionalization.

Authors:  Chi Wai Cheung; Stephen L Buchwald
Journal:  J Org Chem       Date:  2012-08-13       Impact factor: 4.354

3.  Design, Synthesis and Molecular Docking Study of Novel 3-Phenyl-β-Alanine-Based Oxadiazole Analogues as Potent Carbonic Anhydrase II Inhibitors.

Authors:  Kashif Rafiq; Najeeb Ur Rehman; Sobia Ahsan Halim; Majid Khan; Ajmal Khan; Ahmed Al-Harrasi
Journal:  Molecules       Date:  2022-01-26       Impact factor: 4.411

4.  Synthesis of 2,5-diaryloxazoles through rhodium-catalyzed annulation of triazoles and aldehydes.

Authors:  Jian Li; Shang-Rong Zhu; Yue Xu; Xue-Chen Lu; Zheng-Bing Wang; Li Liu; De-Feng Xu
Journal:  RSC Adv       Date:  2020-06-30       Impact factor: 4.036

5.  Oxidative dehydrogenative couplings of pyrazol-5-amines selectively forming azopyrroles.

Authors:  Bo Jiang; Yi Ning; Wei Fan; Shu-Jiang Tu; Guigen Li
Journal:  J Org Chem       Date:  2014-04-22       Impact factor: 4.354
  5 in total

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