Literature DB >> 20680604

Applications of MALDI-MSI to pharmaceutical research.

Brendan Prideaux1, Dieter Staab, Markus Stoeckli.   

Abstract

MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in whole-body tissue sections taken from animals killed at a range of time points postdose. In this example we applied MALDI-MSI to the localization of a compound and its primary metabolite in whole-body mouse sections.

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Year:  2010        PMID： 20680604     DOI： 10.1007/978-1-60761-746-4_23

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  8 in total

Review 1.  Imaging of intact tissue sections: moving beyond the microscope.

Authors:  Erin H Seeley; Kristina Schwamborn; Richard M Caprioli
Journal:  J Biol Chem       Date:  2011-06-01       Impact factor: 5.157

Review 2.  MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications.

Authors:  Benjamin Balluff; Cedrik Schöne; Heinz Höfler; Axel Walch
Journal:  Histochem Cell Biol       Date:  2011-07-30       Impact factor: 4.304

Review 3.  MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice.

Authors:  Michaela Aichler; Axel Walch
Journal:  Lab Invest       Date:  2015-01-26       Impact factor: 5.662

4.  Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization.

Authors:  Mark T Bokhart; Elias Rosen; Corbin Thompson; Craig Sykes; Angela D M Kashuba; David C Muddiman
Journal:  Anal Bioanal Chem       Date:  2014-10-16       Impact factor: 4.142

Review 5.  A vision for better health: mass spectrometry imaging for clinical diagnostics.

Authors:  Hui Ye; Erin Gemperline; Lingjun Li
Journal:  Clin Chim Acta       Date:  2012-10-15       Impact factor: 3.786

6.  Mass Spectrometry Imaging and Structural Analysis of Lipids Directly on Tissue Specimens by Using a Spiral Orbit Type Tandem Time-of-Flight Mass Spectrometer, SpiralTOF-TOF.

Authors:  Takaya Satoh; Ayumi Kubo; Shuichi Shimma; Michisato Toyoda
Journal:  Mass Spectrom (Tokyo)       Date:  2012-11-16

7.  MALDI Mass Spectrometry Imaging for Visualizing In Situ Metabolism of Endogenous Metabolites and Dietary Phytochemicals.

Authors:  Yoshinori Fujimura; Daisuke Miura
Journal:  Metabolites       Date:  2014-05-09

8.  In situ mass spectrometry imaging and ex vivo characterization of renal crystalline deposits induced in multiple preclinical drug toxicology studies.

Authors:  Anna Nilsson; Benita Forngren; Sivert Bjurström; Richard J A Goodwin; Elisa Basmaci; Ingela Gustafsson; Anita Annas; Dennis Hellgren; Alexander Svanhagen; Per E Andrén; Johan Lindberg
Journal:  PLoS One       Date:  2012-10-23       Impact factor: 3.240
  8 in total

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