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Literature DB >> 20680460

Differential patterns of alcohol consumption and dopamine-2 receptor binding in Wistar-Kyoto and Wistar rats.

Abstract

The Wistar-Kyoto (WKY) rat strain has been described as an animal model of depressive behavior that consumes significantly greater amounts of alcohol compared to the Wistar (WIS) rat strain. Since the mesolimbic dopamine (DA) type-2 (D2) receptors mediate reward-related behaviors, the present study measured the binding of [(125)I]-Iodosulpiride to D2 receptors in the brains of WKY versus WIS rats following 24 days of voluntary alcohol or water consumption. Alcohol consuming WKY rats showed a significant increase in D2 receptor binding in several regions of the mesolimbic and nigrostriatal systems. In contrast, alcohol consuming WIS rats showed a reduction in D2 receptor binding in DA cell body areas. The differential regulation of D2 receptors by voluntary alcohol consumption in the two rat strains suggests that D2 receptor mediated neurotransmission may be playing a role in the increased alcohol drinking behavior reported in WKY rats.

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Year: 2010 PMID： 20680460 PMCID： PMC2997530 DOI： 10.1007/s11064-010-0233-0

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

64 in total

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Authors: Richard De La Garza; James J Mahoney
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6. Acquisition of a palatable-food-sustained appetitive behavior in satiated rats is dependent on the dopaminergic response to this food in limbic areas.

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4. Early-life stress affects drug abuse susceptibility in adolescent rat model independently of depression vulnerability.

Authors: Renata L Alves; Pedro Oliveira; Igor M Lopes; Camila C Portugal; Cecília J Alves; Fernando Barbosa; Teresa Summavielle; Ana Magalhães
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4 in total

Differential patterns of alcohol consumption and dopamine-2 receptor binding in Wistar-Kyoto and Wistar rats.

1. Potential use of olanzapine in treatment of substance dependence disorders.

2. Cold-restraint induced gastric lesions in normotensive and spontaneously hypertensive rats.

3. Catecholamine innervation of the basal forebrain. IV. Topography of the dopamine projection to the basal forebrain and neostriatum.

4. Neuroleptic-induced striatal dopamine receptor supersensitivity in mice: relationship to dose and drug.

5. A distinct neurochemical profile in WKY rats at baseline and in response to acute stress: implications for animal models of anxiety and depression.

6. Acquisition of a palatable-food-sustained appetitive behavior in satiated rats is dependent on the dopaminergic response to this food in limbic areas.

7. Wistar Kyoto and Wistar rats differ in the affective and locomotor effects of nicotine.

Review 8. The role of dopamine in locomotor activity and learning.

9. Dopamine receptors in a rat model of minimal brain dysfunction.

10. Strain differences in the expression of dopamine D1 receptors in Wistar-Kyoto (WKY) and Wistar rats.

1. Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex.

Review 2. Alcohol-induced alterations in dopamine modulation of prefrontal activity.

3. Moxidectin Effects on Gut Microbiota of Wistar-Kyoto Rats: Relevance to Depressive-Like Behavior.

4. Early-life stress affects drug abuse susceptibility in adolescent rat model independently of depression vulnerability.