BACKGROUND: Several studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures. AIMS: Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis. METHOD: Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight. RESULTS: The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus. CONCLUSIONS: The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.
BACKGROUND: Several studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures. AIMS: Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis. METHOD: Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight. RESULTS: The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus. CONCLUSIONS: The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.
Authors: Philip Gerretsen; David D Pothier; Carolyn Falls; Maxine Armstrong; Thushanthi Balakumar; Hiroyuki Uchida; David C Mamo; Bruce G Pollock; Ariel Graff-Guerrero Journal: Psychiatry Res Date: 2017-02-13 Impact factor: 3.222
Authors: Philip Gerretsen; M Mallar Chakravarty; David Mamo; Mahesh Menon; Bruce G Pollock; Tarek K Rajji; Ariel Graff-Guerrero Journal: Hum Brain Mapp Date: 2012-01-03 Impact factor: 5.038
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Authors: Philip Gerretsen; Mahesh Menon; David C Mamo; Gagan Fervaha; Gary Remington; Bruce G Pollock; Ariel Graff-Guerrero Journal: Schizophr Res Date: 2014-11-08 Impact factor: 4.939
Authors: Anthony S David; Nicholas Bedford; Ben Wiffen; James Gilleen Journal: Philos Trans R Soc Lond B Biol Sci Date: 2012-05-19 Impact factor: 6.237