Lili Wei1, Haofei Xiong, Bo Li, Yong Cheng, Xing Long. 1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-Most) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Abstract
PURPOSE: This study was conducted to measure the boundary-lubricating ability and lubricin concentration of synovial fluid (SF) from patients with different stages of temporomandibular joint disorders (TMDs) and establish relationships between them. PATIENTS AND METHODS: According to the imaging and clinical findings, TMD patients were divided into 3 subgroups: displaced disc with reduction, displaced disc without reduction, and osteoarthritis. The boundary-lubricating ability of SF was determined by the coefficient of friction (COF) of SF in vitro with a friction apparatus. The lubricin concentrations were quantified by enzyme-linked immunosorbent assays. RESULTS: The COF of SF in TMD patients was significantly higher than that of healthy control subjects, but no observed difference was found among patient subgroups. Furthermore, a significant decline in lubricin concentrations was found in the group with osteoarthritis, whereas there was no significant change in the other groups. However, a significant correlation was not found between the COF and the lubricin concentrations in our study. CONCLUSIONS: These findings showed that distinct changes in lubricin and boundary-lubricating ability in the SF occurred with different stages of TMDs.
PURPOSE: This study was conducted to measure the boundary-lubricating ability and lubricin concentration of synovial fluid (SF) from patients with different stages of temporomandibular joint disorders (TMDs) and establish relationships between them. PATIENTS AND METHODS: According to the imaging and clinical findings, TMDpatients were divided into 3 subgroups: displaced disc with reduction, displaced disc without reduction, and osteoarthritis. The boundary-lubricating ability of SF was determined by the coefficient of friction (COF) of SF in vitro with a friction apparatus. The lubricin concentrations were quantified by enzyme-linked immunosorbent assays. RESULTS: The COF of SF in TMDpatients was significantly higher than that of healthy control subjects, but no observed difference was found among patient subgroups. Furthermore, a significant decline in lubricin concentrations was found in the group with osteoarthritis, whereas there was no significant change in the other groups. However, a significant correlation was not found between the COF and the lubricin concentrations in our study. CONCLUSIONS: These findings showed that distinct changes in lubricin and boundary-lubricating ability in the SF occurred with different stages of TMDs.
Authors: Y Asakawa-Tanne; S Su; R Kunimatsu; N Hirose; T Mitsuyoshi; Y Okamoto; E Tanaka; K Tanne; K Tanimoto Journal: J Dent Res Date: 2014-12-10 Impact factor: 6.116