Literature DB >> 20678557

Potential insulin secretagogue effects of isovitexin and swertisin isolated from Wilbrandia ebracteata roots in non-diabetic rats.

Poliane Folador1, Luisa Helena Cazarolli, Andressa Córneo Gazola, Flávio Henrique Reginatto, Eloir Paulo Schenkel, Fátima Regina Mena Barreto Silva.   

Abstract

The antihyperglycemic effect and mechanism of action of extracts, fractions and compounds from Wilbrandia ebracteata was studied. The crude extract reduced the glycemia, increased glycogen content and serum insulin in hyperglycemic rats. Also, a significant effect was observed with the n-butanol and metanol subfraction. However, the antihyperglycemic effect of the n-butanol fraction was not observed in diabetic rats. The C-glycosylflavones isovitexin and swertisin showed a strong antihyperglycemic action compared with the extracts and fractions. These results show that the extracts, fractions, and isolated C-glycosylflavones have an antihyperglycemic action that was reinforced by the stimulation on in vivo insulin secretion.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20678557     DOI： 10.1016/j.fitote.2010.07.022

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  7 in total

1.  Aleurites moluccana (L.) Willd. Leaves: Mechanical Antinociceptive Properties of a Standardized Dried Extract and Its Chemical Markers.

Authors:  Nara L M Quintão; Christiane Meyre-Silva; Gislaine F Silva; Carla S Antonialli; Lilian W Rocha; Ruth M Lucinda-Silva; Angela Malheiros; Márcia M Souza; Valdir Cechinel Filho; Tania M B Bresolin
Journal:  Evid Based Complement Alternat Med       Date:  2011-03-23       Impact factor: 2.629

2.  Cucumis melo ssp. Agrestis var. Agrestis Ameliorates High Fat Diet Induced Dyslipidemia in Syrian Golden Hamsters and Inhibits Adipogenesis in 3T3-L1 Adipocytes.

Authors:  Kripa Shankar; Sumit K Singh; Durgesh Kumar; Salil Varshney; Abhishek Gupta; Sujith Rajan; Ankita Srivastava; Muheeb Beg; Anurag Kumar Srivastava; Sanjeev Kanojiya; Dipak K Mishra; Anil N Gaikwad
Journal:  Pharmacogn Mag       Date:  2015-10       Impact factor: 1.085

3.  Antioxidant, Anti-inflammatory, Analgesic Properties, and Phytochemical Characterization of Stem Bark Extract and Fractions of Anthocleista nobilis.

Authors:  Kenneth Gerald Ngwoke; Amaka Godsaveus Akwagbulam; Ernest Oghenesuvwe Erhirhie; Daniel Lotanna Ajaghaku; Festus Basden Chiedu Okoye; Charles Okechukwu Esimone
Journal:  Pharmacognosy Res       Date:  2018 Jan-Mar

4.  Short and long-term effects of Baccharis articulata on glucose homeostasis.

Authors:  Virginia D Kappel; Danielle F Pereira; Luisa H Cazarolli; Samantha M Guesser; Carlos H Blum da Silva; Eloir P Schenkel; Flávio H Reginatto; Fátima R M B Silva
Journal:  Molecules       Date:  2012-06-04       Impact factor: 4.411

Review 5.  Phenolic Composition, Mineral Content, and Beneficial Bioactivities of Leaf Extracts from Black Currant (Ribes nigrum L.), Raspberry (Rubus idaeus), and Aronia (Aronia melanocarpa).

Authors:  Monika Staszowska-Karkut; Małgorzata Materska
Journal:  Nutrients       Date:  2020-02-12       Impact factor: 5.717

Review 6.  Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications.

Authors:  Ibrahim Luru Abdulai; Samuel Kojo Kwofie; Winfred Seth Gbewonyo; Daniel Boison; Joshua Buer Puplampu; Michael Buenor Adinortey
Journal:  ScientificWorldJournal       Date:  2021-04-10

7.  Acute Effects of Kawakawa (Piper excelsum) Intake on Postprandial Glycemic and Insulinaemic Response in a Healthy Population.

Authors:  Farha Ramzan; Ramya Jayaprakash; Chris Pook; Meika Foster; Jennifer L Miles-Chan; Richard Mithen
Journal:  Nutrients       Date:  2022-04-14       Impact factor: 6.706
  7 in total

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