Tina D Alkhudhairi1, Eman A Alkofide. 1. Department of Pediatric Dentistry & Orthodontics, King Saud University, College of Dentistry, Riyadh, Saudi Arabia.
Abstract
OBJECTIVE: To estimate the correlation and heritability values of craniofacial variables between parents and their offspring. MATERIALS AND METHODS: The sample comprised 24 Saudi families; each family consisted of father, mother, son, and daughter. Lateral cephalometric radiographs were taken for each family member. Twenty-eight angular, linear, and proportional cephalometric variables were measured. Interfamilial correlations and heritability (h(2)) values were estimated among father-son, father-daughter, mother-son, and mother-daughter pairings. RESULTS: The most similar angular measurements between parents and offspring were related to mandibular variables, which were as follows: MP-SN degrees , MP-FH degrees , SNB degrees , and SNPog degrees ; facial height dimensions and mandibular body length were among the highest similar linear variables. Lower facial height percentage had greater resemblance to parents with regard to proportional measurements. Both the correlation coefficients and the heritable values of these characteristics were stronger in the father-offspring than the mother-offspring pairings. The daughters' cephalometric craniofacial characteristics were more affected by the parents than were those of the sons. CONCLUSIONS: The overall correlation and h(2) mean values for the three types of measurements showed stronger values in the father-offspring than the mother-offspring groups, with the father-daughter pairings more significant than the father-son groups.
OBJECTIVE: To estimate the correlation and heritability values of craniofacial variables between parents and their offspring. MATERIALS AND METHODS: The sample comprised 24 Saudi families; each family consisted of father, mother, son, and daughter. Lateral cephalometric radiographs were taken for each family member. Twenty-eight angular, linear, and proportional cephalometric variables were measured. Interfamilial correlations and heritability (h(2)) values were estimated among father-son, father-daughter, mother-son, and mother-daughter pairings. RESULTS: The most similar angular measurements between parents and offspring were related to mandibular variables, which were as follows: MP-SN degrees , MP-FH degrees , SNB degrees , and SNPog degrees ; facial height dimensions and mandibular body length were among the highest similar linear variables. Lower facial height percentage had greater resemblance to parents with regard to proportional measurements. Both the correlation coefficients and the heritable values of these characteristics were stronger in the father-offspring than the mother-offspring pairings. The daughters' cephalometric craniofacial characteristics were more affected by the parents than were those of the sons. CONCLUSIONS: The overall correlation and h(2) mean values for the three types of measurements showed stronger values in the father-offspring than the mother-offspring groups, with the father-daughter pairings more significant than the father-son groups.
Authors: Joanne B Cole; Mange Manyama; Jacinda R Larson; Denise K Liberton; Tracey M Ferrara; Sheri L Riccardi; Mao Li; Washington Mio; Ophir D Klein; Stephanie A Santorico; Benedikt Hallgrímsson; Richard A Spritz Journal: Genetics Date: 2016-12-14 Impact factor: 4.562
Authors: Matthew C Coombs; Xin She; Truman R Brown; Elizabeth H Slate; Janice S Lee; Hai Yao Journal: J Oral Maxillofac Surg Date: 2019-04-25 Impact factor: 1.895
Authors: Joanne B Cole; Mange Manyama; Emmanuel Kimwaga; Joshua Mathayo; Jacinda R Larson; Denise K Liberton; Ken Lukowiak; Tracey M Ferrara; Sheri L Riccardi; Mao Li; Washington Mio; Michaela Prochazkova; Trevor Williams; Hong Li; Kenneth L Jones; Ophir D Klein; Stephanie A Santorico; Benedikt Hallgrimsson; Richard A Spritz Journal: PLoS Genet Date: 2016-08-25 Impact factor: 5.917