OBJECTIVE: Vascular disease and neuroticism are both risk factors for late-life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late-life. METHODS: Multivariate logistic regression in a survey of 1396 population-dwelling people aged ≥70 years. CRDS were defined as scoring ≥16 on the CES-D. Vascular disease was categorised into four levels: none, ≥2 vascular risk factors, cardiac disease or stroke. RESULTS: Neuroticism was strongly associated with CRDS in women (OR: 1.6, 95% CI: 1.4-1.8). In men vascular disease interacted negatively but significantly with neuroticism (cardiac disease by neuroticism: OR: 0.8, 95% CI: 0.6-0.9; stroke by neuroticism: OR: 0.8, 95% CI: 0.6-0.96) when predicting CRDS. CONCLUSIONS: In men vascular disease attenuates the predictive value of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease.
OBJECTIVE:Vascular disease and neuroticism are both risk factors for late-life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late-life. METHODS: Multivariate logistic regression in a survey of 1396 population-dwelling people aged ≥70 years. CRDS were defined as scoring ≥16 on the CES-D. Vascular disease was categorised into four levels: none, ≥2 vascular risk factors, cardiac disease or stroke. RESULTS: Neuroticism was strongly associated with CRDS in women (OR: 1.6, 95% CI: 1.4-1.8). In menvascular disease interacted negatively but significantly with neuroticism (cardiac disease by neuroticism: OR: 0.8, 95% CI: 0.6-0.9; stroke by neuroticism: OR: 0.8, 95% CI: 0.6-0.96) when predicting CRDS. CONCLUSIONS: In menvascular disease attenuates the predictive value of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease.
Authors: Radboud M Marijnissen; Lonneke Wouts; Robert A Schoevers; Marijke A Bremmer; Aartjan T F Beekman; Hannie C Comijs; Richard C Oude Voshaar Journal: Neurology Date: 2014-10-01 Impact factor: 9.910
Authors: Jeremy S Carmasin; Benjamin T Mast; Jason C Allaire; Keith E Whitfield Journal: Int J Geriatr Psychiatry Date: 2013-07-23 Impact factor: 3.485
Authors: Rita Moretti; Elena Bernobich; Francesca Esposito; Paola Torre; Rodolfo M Antonello; Luisa De Angelis; Giuseppe Bellini Journal: Vasc Health Risk Manag Date: 2011-07-12
Authors: Lonneke Wouts; Marco van Kessel; Aartjan T F Beekman; Radboud M Marijnissen; Richard C Oude Voshaar Journal: Int J Geriatr Psychiatry Date: 2019-10-30 Impact factor: 3.485