Literature DB >> 20676418

Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5.

Adam D Moorhouse1, Christian Spiteri, Pallavi Sharma, Mire Zloh, John E Moses.   

Abstract

hLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5.

Entities:  

Mesh:

Substances:

Year:  2010        PMID: 20676418     DOI: 10.1039/c0cc01166e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  5 in total

Review 1.  Small-molecule inhibitors of human LDH5.

Authors:  Carlotta Granchi; Ilaria Paterni; Reshma Rani; Filippo Minutolo
Journal:  Future Med Chem       Date:  2013-10       Impact factor: 3.808

Review 2.  Anticancer agents that counteract tumor glycolysis.

Authors:  Carlotta Granchi; Filippo Minutolo
Journal:  ChemMedChem       Date:  2012-06-08       Impact factor: 3.466

3.  Identification of New Structural Fragments for the Design of Lactate Dehydrogenase A Inhibitors.

Authors:  D K Nilov; A V Kulikov; E A Prokhorova; V K Švedas
Journal:  Acta Naturae       Date:  2016 Jul-Sep       Impact factor: 1.845

4.  Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase.

Authors:  Sally Dempster; Stephen Harper; John E Moses; Ingrid Dreveny
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2014-04-30

5.  Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells.

Authors:  Julia Billiard; Jennifer B Dennison; Jacques Briand; Roland S Annan; Deping Chai; Mariela Colón; Christopher S Dodson; Seth A Gilbert; Joel Greshock; Junping Jing; Hong Lu; Jeanelle E McSurdy-Freed; Lisa A Orband-Miller; Gordon B Mills; Chad J Quinn; Jessica L Schneck; Gilbert F Scott; Anthony N Shaw; Gregory M Waitt; Richard F Wooster; Kevin J Duffy
Journal:  Cancer Metab       Date:  2013-09-06
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.