Literature DB >> 20675585

Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene.

Magda Forsberg1, Marie Carlén, Konstantinos Meletis, Maggie S Y Yeung, Fanie Barnabé-Heider, Mats A A Persson, Johan Aarum, Jonas Frisén.   

Abstract

Neural stem cells have a broad differentiation repertoire during embryonic development and can be reprogrammed to pluripotency comparatively easily. We report that adult neural stem cells can be reprogrammed at very high efficiency to monocytes, a differentiated fate of an unrelated somatic lineage, by ectopic expression of the Ets transcription factor PU.1. The reprogrammed cells display a marker profile and functional characteristics of monocytes and integrate into tissues after transplantation. The failure to reprogram lineage-committed neural cells to monocytes with PU.1 suggests that neural stem cells are uniquely amenable to reprogramming.

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Year:  2010        PMID： 20675585      PMCID： PMC2930460          DOI： 10.1073/pnas.1009412107

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

Review 1.  Differentiation potential of adult stem cells.

Authors:  D Clarke; J Frisén
Journal:  Curr Opin Genet Dev       Date:  2001-10       Impact factor: 5.578

2.  Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism.

Authors:  V Tropepe; S Hitoshi; C Sirard; T W Mak; J Rossant; D van der Kooy
Journal:  Neuron       Date:  2001-04       Impact factor: 17.173

Review 3.  Nuclear reprogramming to a pluripotent state by three approaches.

Authors:  Shinya Yamanaka; Helen M Blau
Journal:  Nature       Date:  2010-06-10       Impact factor: 49.962

Review 4.  Neural crest cell plasticity and its limits.

Authors:  Nicole M Le Douarin; Sophie Creuzet; Gérard Couly; Elisabeth Dupin
Journal:  Development       Date:  2004-10       Impact factor: 6.868

5.  Plasticity of the differentiated state.

Authors:  H M Blau; G K Pavlath; E C Hardeman; C P Chiu; L Silberstein; S G Webster; S C Miller; C Webster
Journal:  Science       Date:  1985-11-15       Impact factor: 47.728

6.  BMP2 and FGF2 cooperate to induce neural-crest-like fates from fetal and adult CNS stem cells.

Authors:  Martin H M Sailer; Thomas G Hazel; David M Panchision; Daniel J Hoeppner; Martin E Schwab; Ronald D G McKay
Journal:  J Cell Sci       Date:  2005-12-15       Impact factor: 5.285

7.  Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors:  Kazutoshi Takahashi; Shinya Yamanaka
Journal:  Cell       Date:  2006-08-10       Impact factor: 41.582

8.  Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.

Authors:  M W Carr; S J Roth; E Luther; S S Rose; T A Springer
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

Review 9.  Transcriptional control of granulocyte and monocyte development.

Authors:  A D Friedman
Journal:  Oncogene       Date:  2007-10-15       Impact factor: 9.867

10.  In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

Authors:  Qiao Zhou; Juliana Brown; Andrew Kanarek; Jayaraj Rajagopal; Douglas A Melton
Journal:  Nature       Date:  2008-08-27       Impact factor: 49.962
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  16 in total

1.  Regenerative medicine: Heart redevelopment.

Authors:  Richard P Harvey
Journal:  Nature       Date:  2010-09-02       Impact factor: 49.962

Review 2.  G-protein-coupled receptors in adult neurogenesis.

Authors:  Van A Doze; Dianne M Perez
Journal:  Pharmacol Rev       Date:  2012-05-18       Impact factor: 25.468

3.  Pruning of the adipocyte peroxisome proliferator-activated receptor γ cistrome by hematopoietic master regulator PU.1.

Authors:  Joanna R Dispirito; Bin Fang; Fenfen Wang; Mitchell A Lazar
Journal:  Mol Cell Biol       Date:  2013-06-17       Impact factor: 4.272

4.  Direct conversion of human fibroblasts to dopaminergic neurons.

Authors:  Ulrich Pfisterer; Agnete Kirkeby; Olof Torper; James Wood; Jenny Nelander; Audrey Dufour; Anders Björklund; Olle Lindvall; Johan Jakobsson; Malin Parmar
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-06       Impact factor: 11.205

Review 5.  Chemical transdifferentiation: closer to regenerative medicine.

Authors:  Aining Xu; Lin Cheng
Journal:  Front Med       Date:  2016-05-03       Impact factor: 4.592

6.  Valproic Acid Arrests Proliferation but Promotes Neuronal Differentiation of Adult Spinal NSPCs from SCI Rats.

Authors:  Weihua Chu; Jichao Yuan; Lei Huang; Xin Xiang; Haitao Zhu; Fei Chen; Yanyan Chen; Jiangkai Lin; Hua Feng
Journal:  Neurochem Res       Date:  2015-05-29       Impact factor: 3.996

7.  Reconstruction of monocyte transcriptional regulatory network accompanies monocytic functions in human fibroblasts.

Authors:  Takahiro Suzuki; Mika Nakano-Ikegaya; Haruka Yabukami-Okuda; Michiel de Hoon; Jessica Severin; Satomi Saga-Hatano; Jay W Shin; Atsutaka Kubosaki; Christophe Simon; Yuki Hasegawa; Yoshihide Hayashizaki; Harukazu Suzuki
Journal:  PLoS One       Date:  2012-03-13       Impact factor: 3.240

8.  PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin-II by reducing TGF-β1/Smads pathway activation.

Authors:  Juan Hu; Jing-Jing Zhang; Li Li; Shan-Ling Wang; Hai-Tao Yang; Xian-Wei Fan; Lei-Ming Zhang; Guang-Ling Hu; Hai-Xia Fu; Wei-Feng Song; Li-Jie Yan; Jing-Jing Liu; Jin-Tao Wu; Bin Kong
Journal:  J Cell Mol Med       Date:  2021-06-15       Impact factor: 5.310

9.  Cited3 activates Mef2c to control muscle cell differentiation and survival.

Authors:  Gnanapackiam Sheela Devakanmalai; Hasan E Zumrut; Ertuğrul M Ozbudak
Journal:  Biol Open       Date:  2013-04-11       Impact factor: 2.422

Review 10.  Peripheral Blood Monocytes as Adult Stem Cells: Molecular Characterization and Improvements in Culture Conditions to Enhance Stem Cell Features and Proliferative Potential.

Authors:  Hendrik Ungefroren; Ayman Hyder; Maren Schulze; Karim M Fawzy El-Sayed; Evelin Grage-Griebenow; Andreas K Nussler; Fred Fändrich
Journal:  Stem Cells Int       Date:  2015-12-20       Impact factor: 5.443
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