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Literature DB >> 20675499

The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506 reveals several gene clusters responsible for the biosynthesis of toxins and secondary metabolites.

Annick Méjean¹, Rabia Mazmouz, Stéphane Mann, Alexandra Calteau, Claudine Médigue, Olivier Ploux.

Abstract

We report a draft sequence of the genome of Oscillatoria sp. PCC 6506, a cyanobacterium that produces anatoxin-a and homoanatoxin-a, two neurotoxins, and cylindrospermopsin, a cytotoxin. Beside the clusters of genes responsible for the biosynthesis of these toxins, we have found other clusters of genes likely involved in the biosynthesis of not-yet-identified secondary metabolites.

Entities: Species

Mesh：

Substances：
Bacterial Toxins

Year: 2010 PMID： 20675499 PMCID： PMC2944518 DOI： 10.1128/JB.00704-10

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

14 in total

1. Molecular detection of genes responsible for cyanobacterial toxin production in the genera Microcystis, Nodularia, and Cylindrospermopsis.

Authors: Brendan P Burns; Martin L Saker; Michelle C Moffitt; Brett A Neilan
Journal: Methods Mol Biol Date: 2004

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Authors: Marian E van Apeldoorn; Hans P van Egmond; Gerrit J A Speijers; Guido J I Bakker
Journal: Mol Nutr Food Res Date: 2007-01 Impact factor: 5.914

3. Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis.

Authors: Troco Kaan Mihali; Ralf Kellmann; Julia Muenchhoff; Kevin D Barrow; Brett A Neilan
Journal: Appl Environ Microbiol Date: 2007-12-07 Impact factor: 4.792

4. Biosynthesis of cylindrospermopsin and 7-epicylindrospermopsin in Oscillatoria sp. strain PCC 6506: identification of the cyr gene cluster and toxin analysis.

Authors: Rabia Mazmouz; Florence Chapuis-Hugon; Stéphane Mann; Valérie Pichon; Annick Méjean; Olivier Ploux
Journal: Appl Environ Microbiol Date: 2010-06-04 Impact factor: 4.792

Review 5. Isolation and purification of cyanobacteria.

Authors: R Rippka
Journal: Methods Enzymol Date: 1988 Impact factor: 1.600

6. Occurrence of hydrogenases in cyanobacteria and anoxygenic photosynthetic bacteria: implications for the phylogenetic origin of cyanobacterial and algal hydrogenases.

Authors: Marcus Ludwig; Rüdiger Schulz-Friedrich; Jens Appel
Journal: J Mol Evol Date: 2006-11-10 Impact factor: 2.395

7. Evidence that biosynthesis of the neurotoxic alkaloids anatoxin-a and homoanatoxin-a in the cyanobacterium Oscillatoria PCC 6506 occurs on a modular polyketide synthase initiated by L-proline.

Authors: Annick Méjean; Stéphane Mann; Thomas Maldiney; Gaëlle Vassiliadis; Olivier Lequin; Olivier Ploux
Journal: J Am Chem Soc Date: 2009-06-10 Impact factor: 15.419

8. The gas vesicle gene cluster from Microcystis aeruginosa and DNA rearrangements that lead to loss of cell buoyancy.

Authors: Alyssa Mlouka; Katia Comte; Anne-Marie Castets; Christiane Bouchier; Nicole Tandeau de Marsac
Journal: J Bacteriol Date: 2004-04 Impact factor: 3.490

9. Different genotypes of anatoxin-producing cyanobacteria coexist in the Tarn River, France.

Authors: Sabrina Cadel-Six; Caroline Peyraud-Thomas; Luc Brient; Nicole Tandeau de Marsac; Rosmarie Rippka; Annick Méjean
Journal: Appl Environ Microbiol Date: 2007-10-12 Impact factor: 4.792

10. MaGe: a microbial genome annotation system supported by synteny results.

Authors: David Vallenet; Laurent Labarre; Zoé Rouy; Valérie Barbe; Stéphanie Bocs; Stéphane Cruveiller; Aurélie Lajus; Géraldine Pascal; Claude Scarpelli; Claudine Médigue
Journal: Nucleic Acids Res Date: 2006-01-10 Impact factor: 16.971

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Authors: Mohamed S Donia; Eric W Schmidt
Journal: Chem Biol Date: 2011-04-22

Review 2. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.

Authors: Joris Beld; Eva C Sonnenschein; Christopher R Vickery; Joseph P Noel; Michael D Burkart
Journal: Nat Prod Rep Date: 2014-01 Impact factor: 13.423

3. Anatoxin-a synthetase gene cluster of the cyanobacterium Anabaena sp. strain 37 and molecular methods to detect potential producers.

Authors: Anne Rantala-Ylinen; Suvi Känä; Hao Wang; Leo Rouhiainen; Matti Wahlsten; Ermanno Rizzi; Katri Berg; Muriel Gugger; Kaarina Sivonen
Journal: Appl Environ Microbiol Date: 2011-08-26 Impact factor: 4.792

Review 4. The chemical ecology of cyanobacteria.

Authors: Pedro N Leão; Niclas Engene; Agostinho Antunes; William H Gerwick; Vitor Vasconcelos
Journal: Nat Prod Rep Date: 2012-01-12 Impact factor: 13.423

Review 5. Cyanobacterial community succession and associated cyanotoxin production in hypereutrophic and eutrophic freshwaters.

Authors: Rahamat Ullah Tanvir; Zhiqiang Hu; Yanyan Zhang; Jingrang Lu
Journal: Environ Pollut Date: 2021-08-27 Impact factor: 8.071

6. Identification of homophenylalanine biosynthetic genes from the cyanobacterium Nostoc punctiforme PCC73102 and application to its microbial production by Escherichia coli.

Authors: Kento Koketsu; Satoshi Mitsuhashi; Kazuhiko Tabata
Journal: Appl Environ Microbiol Date: 2013-01-25 Impact factor: 4.792

7. Elucidation of insertion elements carried on plasmids and in vitro construction of shuttle vectors from the toxic cyanobacterium Planktothrix.

Authors: Guntram Christiansen; Alexander Goesmann; Rainer Kurmayer
Journal: Appl Environ Microbiol Date: 2014-06-06 Impact factor: 4.792