| Literature DB >> 20675158 |
Felisbina L Queiroga1, Isabel Pires, Margarida Parente, Hugo Gregório, Carlos S Lopes.
Abstract
This study was designed to investigate the possible roles of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in canine mammary cancer angiogenesis. Immunohistochemistry was performed on 70 tumours (28 benign and 42 malignant) in order to detect COX-2 and VEGF expression. Microvessel density (MVD) was determined by CD31 immunolabelling to assess tumour angiogenesis. There was a significantly higher expression of COX-2 (P<0.001), VEGF (P<0.001) and MVD (P<0.001) in malignant compared to benign tumours. In the malignant group, the MVD of COX-2 positive tumours was significantly higher than that of COX-2 negative tumours (P=0.026). A similar association was observed for VEGF (P<0.001) positive tumours. The results from this study suggested that over-expression of COX-2 and VEGF may contribute to increased angiogenesis and aggression in malignant tumours.Entities:
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Year: 2010 PMID： 20675158 DOI： 10.1016/j.tvjl.2010.06.022
Source DB: PubMed Journal: Vet J ISSN： 1090-0233 Impact factor: 2.688