BACKGROUNDS: To determine the association between the brain derived neurotrophic factor (BDNF) Val66Met polymorphism and short-term antidepressant response in Taiwanese patients with major depressive disorder (MDD). METHODS: We recruited 117 MDD patients who were randomized tofluoxetine or venlafaxinetreatment and 106 controls. The association between genotypes and percentage changes in the Hamilton Rating Scale for Depression (HAM-D) scores over time was analyzed by repeated-measures ANOVA. The antidepressants were included in the model as covariates. RESULTS: The frequency of the BDNF Val66Met polymorphisms was not significantly different between patient and control groups. Significantly changes in HAM-D scores were noted after 2 and 4 weeks of venlafaxine treatment among different genotypes. CONCLUSIONS: Results suggest antidepressants acting through different mechanisms may affect the BDNF Val66Met polymorphism differently.
RCT Entities:
BACKGROUNDS: To determine the association between the brain derived neurotrophic factor (BDNF) Val66Met polymorphism and short-term antidepressant response in Taiwanese patients with major depressive disorder (MDD). METHODS: We recruited 117 MDDpatients who were randomized to fluoxetine or venlafaxine treatment and 106 controls. The association between genotypes and percentage changes in the Hamilton Rating Scale for Depression (HAM-D) scores over time was analyzed by repeated-measures ANOVA. The antidepressants were included in the model as covariates. RESULTS: The frequency of the BDNF Val66Met polymorphisms was not significantly different between patient and control groups. Significantly changes in HAM-D scores were noted after 2 and 4 weeks of venlafaxine treatment among different genotypes. CONCLUSIONS: Results suggest antidepressants acting through different mechanisms may affect the BDNF Val66Met polymorphism differently.
Authors: Bo Cao; Isabelle E Bauer; Ajaykumar N Sharma; Benson Mwangi; Thomas Frazier; Luca Lavagnino; Giovana B Zunta-Soares; Consuelo Walss-Bass; David C Glahn; Flavio Kapczinski; David A Nielsen; Jair C Soares Journal: J Affect Disord Date: 2016-03-10 Impact factor: 4.839
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