Respiratory infections due to drug-resistant bacteria.

Pneumonia is the most common infection that is the leading cause of death. The increasing antimicrobial resistance in major respiratory pathogens such as Streptococcus pneumoniae, Staphylococcus aureus and gram-negative bacteria has severely restricted the treatment options. Respiratory infections caused by multidrug-resistant bacteria are associated with a greater likelihood of inappropriate antimicrobial therapy and poor clinical outcome. Especially, treatment of infections caused by pandrug-resistant gram-negative bacteria is a major challenge. Continuous efforts to control the global spread of drug-resistant bacteria are essential. Copyright 2010 Elsevier Inc. All rights reserved.