Literature DB >> 20674545

Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration.

Zhongjian Xie1, Jian Peng, Sally D Pennypacker, Ying Chen.   

Abstract

Phospholipase C-gamma1 (PLC-gamma1), a tyrosine kinase substrate, has been implicated in the pathway for the epidermal growth factor receptor (EGFR)-induced cell migration. However, the underlying mechanism by which PLC-gamma1 mediates EGFR-induced cell migration remains elusive. In the present study, we sought to determine whether the lipase activity of PLC-gamma1 is required for EGFR-induced cell migration. We found that overexpression of PLC-gamma1 in squamous cell carcinoma SCC4 cells markedly enhanced EGF-induced PLC-gamma1 activation, intracellular calcium rise, and cell migration. This enhancement was abolished by mutational inactivation of the catalytic domain of PLC-gamma1. Inhibition of the downstream signaling processes mediated by the activity of phospholipase C (PLC) using IP(3) receptor inhibitor or intracellular calcium chelator blocked EGF-induced cell migration. These data indicate that EGF-induced cell migration is mediated by the lipase domain of PLC-gamma1 and the subsequent IP(3) generation and intracellular calcium mobilization. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20674545      PMCID： PMC2933433          DOI： 10.1016/j.bbrc.2010.07.098

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  31 in total

1.  Inhibiting neuronal migration by blocking NMDA receptors in the embryonic rat cerebral cortex: a tissue culture study.

Authors:  K Hirai; H Yoshioka; M Kihara; K Hasegawa; T Sakamoto; T Sawada; S Fushiki
Journal:  Brain Res Dev Brain Res       Date:  1999-04-12

2.  Comparison of methods for transfection of human epidermal keratinocytes.

Authors:  C K Jiang; D Connolly; M Blumenberg
Journal:  J Invest Dermatol       Date:  1991-12       Impact factor: 8.551

3.  Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity.

Authors:  D B Polk
Journal:  Gastroenterology       Date:  1998-03       Impact factor: 22.682

4.  Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates.

Authors:  S Khoshyomn; P L Penar; J Rossi; A Wells; D L Abramson; A Bhushan
Journal:  Neurosurgery       Date:  1999-03       Impact factor: 4.654

5.  Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

Authors:  J E Bleasdale; N R Thakur; R S Gremban; G L Bundy; F A Fitzpatrick; R J Smith; S Bunting
Journal:  J Pharmacol Exp Ther       Date:  1990-11       Impact factor: 4.030

6.  Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues.

Authors:  D Y Noh; Y H Lee; S S Kim; Y I Kim; S H Ryu; P G Suh; J G Park
Journal:  Cancer       Date:  1994-01-01       Impact factor: 6.860

7.  Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.

Authors:  R J Smith; L M Sam; J M Justen; G L Bundy; G A Bala; J E Bleasdale
Journal:  J Pharmacol Exp Ther       Date:  1990-05       Impact factor: 4.030

8.  Endothelial myosin light chain kinase regulates neutrophil migration across human umbilical vein endothelial cell monolayer.

Authors:  H Saito; Y Minamiya; M Kitamura; S Saito; K Enomoto; K Terada; J Ogawa
Journal:  J Immunol       Date:  1998-08-01       Impact factor: 5.422

9.  Gelsolin modulates phospholipase C activity in vivo through phospholipid binding.

Authors:  H q Sun; K m Lin; H L Yin
Journal:  J Cell Biol       Date:  1997-08-25       Impact factor: 10.539

10.  Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement.

Authors:  P Chen; H Xie; M C Sekar; K Gupta; A Wells
Journal:  J Cell Biol       Date:  1994-11       Impact factor: 10.539
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  9 in total

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Journal:  Am J Pathol       Date:  2012-05-23       Impact factor: 4.307

3.  Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts.

Authors:  Evita M Lindholm; Alexandr Kristian; Hawa Nalwoga; Kristi Krüger; Ståle Nygård; Lars A Akslen; Gunhild M Mælandsmo; Olav Engebraaten
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4.  Second messenger role for Mg2+ revealed by human T-cell immunodeficiency.

Authors:  Feng-Yen Li; Benjamin Chaigne-Delalande; Chrysi Kanellopoulou; Jeremiah C Davis; Helen F Matthews; Daniel C Douek; Jeffrey I Cohen; Gulbu Uzel; Helen C Su; Michael J Lenardo
Journal:  Nature       Date:  2011-07-27       Impact factor: 49.962

5.  Novel BAG3 Variants in African American Patients With Cardiomyopathy: Reduced β-Adrenergic Responsiveness in Excitation-Contraction.

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6.  PKG II inhibits EGF/EGFR-induced migration of gastric cancer cells.

Authors:  Lu Jiang; Ting Lan; Yongchang Chen; Jianrong Sang; Yueying Li; Min Wu; Yan Tao; Ying Wang; Hai Qian; Luo Gu
Journal:  PLoS One       Date:  2013-04-16       Impact factor: 3.240

7.  Type II cGMP-dependent protein kinase inhibits epidermal growth factor-induced phosphatidylinositol-3-kinase/Akt signal transduction in gastric cancer cells.

Authors:  Min Wu; Yongchang Chen; Lu Jiang; Yueying Li; Ting Lan; Ying Wang; Hai Qian
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8.  The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease.

Authors:  Valerie D Myers; Joseph M McClung; JuFang Wang; Farzaneh G Tahrir; Manish K Gupta; Jennifer Gordon; Christopher H Kontos; Kamel Khalili; Joseph Y Cheung; Arthur M Feldman
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Review 9.  Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes.

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Journal:  Cells       Date:  2020-03-12       Impact factor: 6.600
  9 in total

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