Literature DB >> 20673725

Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives.

Hamid Nadri1, Morteza Pirali-Hamedani, Maryam Shekarchi, Mohammad Abdollahi, Vahid Sheibani, Massoud Amanlou, Abbas Shafiee, Alireza Foroumadi.   

Abstract

A novel series of benzofuranone-ylidene-methyl benzylpyridinium derivatives (6a-u) were synthesized as acetylcholinesterase inhibitors. The anticholinesterase activity of synthesized compounds was measured using colorimetric Ellman's method. It was revealed that some synthesized compounds exhibited high anticholinesterase activity, among them compound 6b was the most active compound (IC(50)=10 + or - 6.87 nM). Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20673725     DOI： 10.1016/j.bmc.2010.07.012

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  10 in total

Review 1.  Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer's disease.

Authors:  Pritam Thapa; Sunil P Upadhyay; William Z Suo; Vikas Singh; Prajwal Gurung; Eung Seok Lee; Ram Sharma; Mukut Sharma
Journal:  Bioorg Chem       Date:  2021-01-29       Impact factor: 5.307

2.  A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine.

Authors:  Seyed Behzad Jazayeri; Arash Amanlou; Naghmeh Ghanadian; Parvin Pasalar; Massoud Amanlou
Journal:  Daru       Date:  2014-01-08       Impact factor: 3.117

3.  Synthesis and Acetylcholinesterase Inhibitory Evaluation of 4-(1,3-Dioxoisoindolin-2-yl)-N-Phenyl Benzamide Derivatives as Potential Anti-Alzheimer Agents.

Authors:  Ahmad Mohammadi-Farani; Samira Soltani Darbandi; Alireza Aliabadi
Journal:  Iran J Pharm Res       Date:  2016       Impact factor: 1.696

4.  2-(2-(4-Benzoylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives: Synthesis, docking and acetylcholinesterase inhibitory evaluation as anti-alzheimer agents.

Authors:  Ahmad Mohammadi-Farani; Nasibeh Abdi; Alireza Moradi; Alireza Aliabadi
Journal:  Iran J Basic Med Sci       Date:  2017-01       Impact factor: 2.699

Review 5.  Profiling donepezil template into multipotent hybrids with antioxidant properties.

Authors:  Eva Mezeiova; Katarina Spilovska; Eugenie Nepovimova; Lukas Gorecki; Ondrej Soukup; Rafael Dolezal; David Malinak; Jana Janockova; Daniel Jun; Kamil Kuca; Jan Korabecny
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

6.  Novel 3-aminobenzofuran derivatives as multifunctional agents for the treatment of Alzheimer's disease.

Authors:  Zaman Hasanvand; Rasoul Motahari; Hamid Nadri; Setareh Moghimi; Roham Foroumadi; Adileh Ayati; Tahmineh Akbarzadeh; Syed Nasir Abbas Bukhari; Alireza Foroumadi
Journal:  Front Chem       Date:  2022-08-09       Impact factor: 5.545

Review 7.  Recent developments in the design and synthesis of benzylpyridinium salts: Mimicking donepezil hydrochloride in the treatment of Alzheimer's disease.

Authors:  Saghi Sepehri; Mina Saeedi; Bagher Larijani; Mohammad Mahdavi
Journal:  Front Chem       Date:  2022-09-26       Impact factor: 5.545

8.  5,6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety.

Authors:  Hamid Nadri; Morteza Pirali-Hamedani; Alireza Moradi; Amirhossein Sakhteman; Alireza Vahidi; Vahid Sheibani; Ali Asadipour; Nouraddin Hosseinzadeh; Mohammad Abdollahi; Abbas Shafiee; Alireza Foroumadi
Journal:  Daru       Date:  2013-02-27       Impact factor: 3.117

9.  Synthesis, docking and acetylcholinesterase inhibitory assessment of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives with potential anti-Alzheimer effects.

Authors:  Ahmad Mohammadi-Farani; Aram Ahmadi; Hamid Nadri; Alireza Aliabadi
Journal:  Daru       Date:  2013-06-07       Impact factor: 3.117

10.  Synthesis and Evaluation of Anti-acetylcholinesterase Activity of 2-(2-(4-(2-Oxo-2-phenylethyl)piperazin-1-yl) ethyl)Isoindoline-1,3-dione Derivatives with Potential Anti-Alzheimer Effects.

Authors:  Alireza Aliabadi; Alireza Foroumadi; Ahmad Mohammadi-Farani; Mahdi Garmsiri Mahvar
Journal:  Iran J Basic Med Sci       Date:  2013-10       Impact factor: 2.699
  10 in total

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