BACKGROUND: The purpose of this study was to evaluate the association between preoperative plasma fibrinogen levels on clinicopathologic parameters and overall survival in patients after curative resection with colorectal cancer. METHODS: Preoperative plasma fibrinogen levels were examined in 341 patients who underwent curative resection for colorectal cancer. Preoperative plasma fibrinogen levels were correlated with clinicopathologic findings and disease-specific overall survival. RESULTS: Mean (±SD) preoperative plasma fibrinogen levels were 369.9 mg/dl (±69.1 mg/dl). Elevated plasma fibrinogen levels were associated with advanced tumor stage (P = 0.008), venous invasion (P = 0.006), and postoperative distant metastases (P < 0.001), but not with histologic grade (P = 0.232), invasion depth (P = 0.253), and lymph node involvement (P = 0.136). Multivariate analysis showed that preoperative plasma fibrinogen levels (P = 0.029), histologic grade (P = 0.001), and lymph node involvement (P = 0.001) were defined as independent prognostic factors. CONCLUSIONS: High preoperative plasma fibrinogen levels are associated with distant metastases and impaired prognosis after curative resection in patients with colorectal cancer. J. Surg. Oncol. 2010;102:428-432.
BACKGROUND: The purpose of this study was to evaluate the association between preoperative plasma fibrinogen levels on clinicopathologic parameters and overall survival in patients after curative resection with colorectal cancer. METHODS: Preoperative plasma fibrinogen levels were examined in 341 patients who underwent curative resection for colorectal cancer. Preoperative plasma fibrinogen levels were correlated with clinicopathologic findings and disease-specific overall survival. RESULTS: Mean (±SD) preoperative plasma fibrinogen levels were 369.9 mg/dl (±69.1 mg/dl). Elevated plasma fibrinogen levels were associated with advanced tumor stage (P = 0.008), venous invasion (P = 0.006), and postoperative distant metastases (P < 0.001), but not with histologic grade (P = 0.232), invasion depth (P = 0.253), and lymph node involvement (P = 0.136). Multivariate analysis showed that preoperative plasma fibrinogen levels (P = 0.029), histologic grade (P = 0.001), and lymph node involvement (P = 0.001) were defined as independent prognostic factors. CONCLUSIONS: High preoperative plasma fibrinogen levels are associated with distant metastases and impaired prognosis after curative resection in patients with colorectal cancer. J. Surg. Oncol. 2010;102:428-432.
Authors: Thomas E Ichim; Boris Minev; Todd Braciak; Brandon Luna; Ron Hunninghake; Nina A Mikirova; James A Jackson; Michael J Gonzalez; Jorge R Miranda-Massari; Doru T Alexandrescu; Constantin A Dasanu; Vladimir Bogin; Janis Ancans; R Brian Stevens; Boris Markosian; James Koropatnick; Chien-Shing Chen; Neil H Riordan Journal: J Transl Med Date: 2011-03-04 Impact factor: 5.531
Authors: David Zaragoza-Huesca; Andrés Nieto-Olivares; Francisco García-Molina; Guillermo Ricote; Sofía Montenegro; Manuel Sánchez-Cánovas; Pedro Garrido-Rodríguez; Julia Peñas-Martínez; Vicente Vicente; Francisco Martínez; María Luisa Lozano; Alberto Carmona-Bayonas; Irene Martínez-Martínez Journal: Cancers (Basel) Date: 2022-06-24 Impact factor: 6.575