Literature DB >> 2067143

The role of capsaicin-sensitive afferent nerves in protective effect of capsaicin against absolute ethanol-induced gastric lesions in rats.

M Uchida1, S Yano, K Watanabe.   

Abstract

The role of capsaicin-sensitive afferent nerves in gastroprotection by capsaicin was investigated in the absolute ethanol-induced gastric lesion model in rats. Capsaicin (0.1 and 0.5 mg/kg, p.o.) inhibited the lesion formation dose-dependently. The protective effect of capsaicin was attenuated by indomethacin-pretreatment and disappeared in capsaicin-sensitive nerve degenerated rats. Capsaicin did not induce the distension of gastric mucosal folds. These results suggested that stimulation of capsaicin-sensitive afferent nerves by capsaicin would enhance the prostaglandin formation, leading to an inhibition of gastric lesions.

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Year:  1991        PMID： 2067143     DOI： 10.1254/jjp.55.279

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN： 0021-5198


  8 in total

1.  Role of capsaicin sensitive nerves in epidermal growth factor effects on gastric mucosal injury and blood flow.

Authors:  J Y Kang; C H Teng; F C Chen; A Wee
Journal:  Gut       Date:  1998-03       Impact factor: 23.059

2.  Suppression of tumor necrosis factor-α-induced nuclear factor κB activation and aromatase activity by capsaicin and its analog capsazepine.

Authors:  Suaib Luqman; Abha Meena; Laura E Marler; Tamara P Kondratyuk; John M Pezzuto
Journal:  J Med Food       Date:  2011-06-11       Impact factor: 2.786

3.  Role of capsaicin-sensitive sensory nerves in acid-induced bicarbonate secretion in rat stomach.

Authors:  K Takeuchi; K Ueshima; J Matsumoto; S Okabe
Journal:  Dig Dis Sci       Date:  1992-05       Impact factor: 3.199

4.  Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins.

Authors:  Kazuhiro Fukushima; Yoko Aoi; Shinichi Kato; Koji Takeuchi
Journal:  World J Gastroenterol       Date:  2006-05-21       Impact factor: 5.742

5.  Effect of capsaicin and chilli on ethanol induced gastric mucosal injury in the rat.

Authors:  J Y Kang; C H Teng; A Wee; F C Chen
Journal:  Gut       Date:  1995-05       Impact factor: 23.059

6.  Nitric oxide in gastroprotection by sucralfate, mild irritant, and nocloprost. Role of mucosal blood flow.

Authors:  S J Konturek; T Brzozowski; J Majka; A Szlachcic; K Czarnobilski
Journal:  Dig Dis Sci       Date:  1994-03       Impact factor: 3.199

Review 7.  Biological Properties, Bioactive Constituents, and Pharmacokinetics of Some Capsicum spp. and Capsaicinoids.

Authors:  Gaber El-Saber Batiha; Ali Alqahtani; Oluwafemi Adeleke Ojo; Hazem M Shaheen; Lamiaa Wasef; Mahmoud Elzeiny; Mahmoud Ismail; Mahmoud Shalaby; Toshihiro Murata; Adrian Zaragoza-Bastida; Nallely Rivero-Perez; Amany Magdy Beshbishy; Keneth Iceland Kasozi; Philippe Jeandet; Helal F Hetta
Journal:  Int J Mol Sci       Date:  2020-07-22       Impact factor: 5.923

8.  QSAR and docking studies on capsazepine derivatives for immunomodulatory and anti-inflammatory activity.

Authors:  Aparna Shukla; Pooja Sharma; Om Prakash; Monika Singh; Komal Kalani; Feroz Khan; Dnyaneshwar Umrao Bawankule; Suaib Luqman; Santosh Kumar Srivastava
Journal:  PLoS One       Date:  2014-07-08       Impact factor: 3.240
  8 in total

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