Literature DB >> 20670688

The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress.

Thorbald van Hall1, Claudia C Oliveira, Simone A Joosten, Tom H M Ottenhoff.   

Abstract

The non-polymorphic MHC molecule Qa-1 and its human counterpart HLA-E present monomorphic signal peptides to innate receptors and thereby regulate lymphocyte activity. Under stress, this peptide content is replaced with a surprisingly diverse repertoire of novel peptides that are associated with heat-shock proteins, infectious agents or antigen processing defects.
Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.

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Year:  2010        PMID： 20670688     DOI： 10.1016/j.micinf.2010.07.011

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  27 in total

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8.  Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues.

Authors:  Paula Ruibal; Kees L M C Franken; Krista E van Meijgaarden; Joeri J F van Loon; Dirk van der Steen; Mirjam H M Heemskerk; Tom H M Ottenhoff; Simone A Joosten
Journal:  J Immunol       Date:  2020-10-05       Impact factor: 5.422

9.  Qa-1b Modulates Resistance to Anti-PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing.

Authors:  Xiao Zhang; Erich Sabio; Chirag Krishna; Xiaoxiao Ma; Jingming Wang; Hui Jiang; Jonathan J Havel; Timothy A Chan
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10.  Broadly targeted CD8⁺ T cell responses restricted by major histocompatibility complex E.

Authors:  Scott G Hansen; Helen L Wu; Benjamin J Burwitz; Colette M Hughes; Katherine B Hammond; Abigail B Ventura; Jason S Reed; Roxanne M Gilbride; Emily Ainslie; David W Morrow; Julia C Ford; Andrea N Selseth; Reesab Pathak; Daniel Malouli; Alfred W Legasse; Michael K Axthelm; Jay A Nelson; Geraldine M Gillespie; Lucy C Walters; Simon Brackenridge; Hannah R Sharpe; César A López; Klaus Früh; Bette T Korber; Andrew J McMichael; S Gnanakaran; Jonah B Sacha; Louis J Picker
Journal:  Science       Date:  2016-01-21       Impact factor: 47.728
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