OBJECTIVE: For severe, critical and fatal cases of 2009 H1N1 influenza in the winter in the Northern Hemisphere, the detailed features are not fully known. The aim of this study was to examine these features through describing these cases in Beijing, China in 2009. METHODS: Data on severe, critical and fatal cases were collected via the Notifiable Disease Surveillance System and a designated surveillance system for managing 2009 H1N1 influenza cases in Beijing. The characteristics and risk factors of these cases were elucidated. RESULTS: A total of 475 severe cases, 73 critical ones and 69 deaths were identified in 2009. The proportion of obesity was low, as well as pregnancy. About half of them had no underlying disease. Most of deaths had multi-organ failure, with a median interval from illness onset to death of ten days. Delay in visiting hospital, cardiovascular disease and allergy predicted a higher risk of severe disease, and cases aged 6-17 years were at lower risk. Cases not promptly receiving neuraminidase inhibitors were at increased risk of death. CONCLUSIONS: Age and underlying disease are significantly associated with severity of outcomes of 2009 H1N1 influenza; prompt presentation to hospital and use of neuraminidase inhibitor were protective.
OBJECTIVE: For severe, critical and fatal cases of 2009 H1N1 influenza in the winter in the Northern Hemisphere, the detailed features are not fully known. The aim of this study was to examine these features through describing these cases in Beijing, China in 2009. METHODS: Data on severe, critical and fatal cases were collected via the Notifiable Disease Surveillance System and a designated surveillance system for managing 2009 H1N1 influenza cases in Beijing. The characteristics and risk factors of these cases were elucidated. RESULTS: A total of 475 severe cases, 73 critical ones and 69 deaths were identified in 2009. The proportion of obesity was low, as well as pregnancy. About half of them had no underlying disease. Most of deaths had multi-organ failure, with a median interval from illness onset to death of ten days. Delay in visiting hospital, cardiovascular disease and allergy predicted a higher risk of severe disease, and cases aged 6-17 years were at lower risk. Cases not promptly receiving neuraminidase inhibitors were at increased risk of death. CONCLUSIONS: Age and underlying disease are significantly associated with severity of outcomes of 2009 H1N1 influenza; prompt presentation to hospital and use of neuraminidase inhibitor were protective.
Authors: Jonathan Hsu; Nancy Santesso; Reem Mustafa; Jan Brozek; Yao Long Chen; Jessica P Hopkins; Adrienne Cheung; Gayane Hovhannisyan; Liudmila Ivanova; Signe A Flottorp; Ingvil Saeterdal; Arthur D Wong; Jinhui Tian; Timothy M Uyeki; Elie A Akl; Pablo Alonso-Coello; Fiona Smaill; Holger J Schünemann Journal: Ann Intern Med Date: 2012-02-27 Impact factor: 25.391
Authors: Maria D Van Kerkhove; Katelijn A H Vandemaele; Vivek Shinde; Giovanna Jaramillo-Gutierrez; Artemis Koukounari; Christl A Donnelly; Luis O Carlino; Rhonda Owen; Beverly Paterson; Louise Pelletier; Julie Vachon; Claudia Gonzalez; Yu Hongjie; Feng Zijian; Shuk Kwan Chuang; Albert Au; Silke Buda; Gerard Krause; Walter Haas; Isabelle Bonmarin; Kiyosu Taniguichi; Kensuke Nakajima; Tokuaki Shobayashi; Yoshihiro Takayama; Tomi Sunagawa; Jean Michel Heraud; Arnaud Orelle; Ethel Palacios; Marianne A B van der Sande; C C H Lieke Wielders; Darren Hunt; Jeffrey Cutter; Vernon J Lee; Juno Thomas; Patricia Santa-Olalla; Maria J Sierra-Moros; Wanna Hanshaoworakul; Kumnuan Ungchusak; Richard Pebody; Seema Jain; Anthony W Mounts Journal: PLoS Med Date: 2011-07-05 Impact factor: 11.069
Authors: Stefan P Kuster; Kevin C Katz; Joanne Blair; James Downey; Steven J Drews; Sandy Finkelstein; Rob Fowler; Karen Green; Jonathan Gubbay; Kazi Hassan; Stephen E Lapinsky; Tony Mazzulli; Donna McRitchie; Janos Pataki; Agron Plevneshi; Jeff Powis; David Rose; Alicia Sarabia; Carmine Simone; Andrew Simor; Allison McGeer Journal: Crit Care Date: 2011-07-28 Impact factor: 9.097
Authors: Paula E Miller; Aksharananda Rambachan; Roderick J Hubbard; Jiabai Li; Alison E Meyer; Peter Stephens; Anthony W Mounts; Melissa A Rolfes; Charles R Penn Journal: PLoS One Date: 2012-09-11 Impact factor: 3.240