OBJECTIVE: To review the association between clinical signs and diagnostic findings and the survival time of dogs with dilated cardiomyopathy (DCM), and any influence of treatment prescribed. METHODS: A retrospective observational study of 367 dogs with DCM. Survival times until death or euthanasia for cardiac reasons were analysed using the Kaplan-Meier method plus univariate and multivariate Cox proportional hazards models. Two-tailed P values less than 0.05 were considered statistically significant. RESULTS: In the multivariate model, left ventricular diameter (LVDs)-index (P=0.0067), presence of pulmonary oedema on radiography (P=0.043), presence of ventricular premature complexes (VPCs) (P=0.0012), higher plasma creatinine (P=0.0002), lower plasma protein (P=0.029) and great Dane breed (P=0.0003) were negatively associated with survival. Most dogs were treated with angiotensin-converting enzyme inhibitors (93%) or furosemide (86%), and many received digoxin (50%) and/or pimobendan (30%). Thirteen dogs were lost to follow-up. No conclusions could be made in this study on the association between use of drugs and survival. CLINICAL SIGNIFICANCE: The LVDs-index was the single best variable for assessing the prognosis in this group of dogs with DCM. Other variables that were negatively associated with survival were presence of pulmonary oedema on radiography, presence of VPCs, higher plasma creatinine, lower plasma protein and great Dane breed.
OBJECTIVE: To review the association between clinical signs and diagnostic findings and the survival time of dogs with dilated cardiomyopathy (DCM), and any influence of treatment prescribed. METHODS: A retrospective observational study of 367 dogs with DCM. Survival times until death or euthanasia for cardiac reasons were analysed using the Kaplan-Meier method plus univariate and multivariate Cox proportional hazards models. Two-tailed P values less than 0.05 were considered statistically significant. RESULTS: In the multivariate model, left ventricular diameter (LVDs)-index (P=0.0067), presence of pulmonary oedema on radiography (P=0.043), presence of ventricular premature complexes (VPCs) (P=0.0012), higher plasma creatinine (P=0.0002), lower plasma protein (P=0.029) and great Dane breed (P=0.0003) were negatively associated with survival. Most dogs were treated with angiotensin-converting enzyme inhibitors (93%) or furosemide (86%), and many received digoxin (50%) and/or pimobendan (30%). Thirteen dogs were lost to follow-up. No conclusions could be made in this study on the association between use of drugs and survival. CLINICAL SIGNIFICANCE: The LVDs-index was the single best variable for assessing the prognosis in this group of dogs with DCM. Other variables that were negatively associated with survival were presence of pulmonary oedema on radiography, presence of VPCs, higher plasma creatinine, lower plasma protein and great Dane breed.
Authors: Deborah M Fine; Jin-Hong Shin; Yongping Yue; Dietrich Volkmann; Stacey B Leach; Bruce F Smith; Mark McIntosh; Dongsheng Duan Journal: Neuromuscul Disord Date: 2011-05-13 Impact factor: 4.296
Authors: Darcy Adin; Lisa Freeman; Rebecca Stepien; John E Rush; Sonja Tjostheim; Heidi Kellihan; Michael Aherne; Michelle Vereb; Robert Goldberg Journal: J Vet Intern Med Date: 2021-02-27 Impact factor: 3.333
Authors: Kathryn Taggart; Amara Estrada; Patrick Thompson; Francisco Lourenco; Sara Kirmani; Silveli Suzuki-Hatano; Christina A Pacak Journal: Biores Open Access Date: 2017-12-01
Authors: N J Summerfield; A Boswood; M R O'Grady; S G Gordon; J Dukes-McEwan; M A Oyama; S Smith; M Patteson; A T French; G J Culshaw; L Braz-Ruivo; A Estrada; M L O'Sullivan; J Loureiro; R Willis; P Watson Journal: J Vet Intern Med Date: 2012-10-18 Impact factor: 3.333
Authors: Siobhan Simpson; Jennifer Edwards; Thomas F N Ferguson-Mignan; Malcolm Cobb; Nigel P Mongan; Catrin S Rutland Journal: Int J Genomics Date: 2015-07-22 Impact factor: 2.326
Authors: Lance C Visser; Joanna L Kaplan; Satoko Nishimura; Catherine T Gunther-Harrington; Catherine Bélanger; Maureen S Oldach; Joshua A Stern; Mikaela S Mueller Journal: J Vet Intern Med Date: 2018-07-03 Impact factor: 3.333