Literature DB >> 20669933

Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica.

Giuseppina Chianese1, Serge R Yerbanga, Leonardo Lucantoni, Annette Habluetzel, Nicoletta Basilico, Donatella Taramelli, Ernesto Fattorusso, Orazio Taglialatela-Scafati.   

Abstract

Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.

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Year:  2010        PMID： 20669933     DOI： 10.1021/np100325q

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  14 in total

1.  Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.

Authors:  Subash C Gupta; Sajin K Francis; Mangalam S Nair; Yin-Yuan Mo; Bharat B Aggarwal
Journal:  J Biol Chem       Date:  2013-09-27       Impact factor: 5.157

2.  In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region.

Authors:  Nawal M Al-Musayeib; Ramzi A Mothana; An Matheeussen; Paul Cos; Louis Maes
Journal:  BMC Complement Altern Med       Date:  2012-04-20       Impact factor: 3.659

3.  Impact of repeated NeemAzal-treated blood meals on the fitness of Anopheles stephensi mosquitoes.

Authors:  Edson G Dembo; Solomon M Abay; Nisha Dahiya; Johnbull S Ogboi; George K Christophides; Giulio Lupidi; Giuseppina Chianese; Leonardo Lucantoni; Annette Habluetzel
Journal:  Parasit Vectors       Date:  2015-02-10       Impact factor: 3.876

4.  Gedunin and Azadiradione: Human Pancreatic Alpha-Amylase Inhibiting Limonoids from Neem (Azadirachta indica) as Anti-Diabetic Agents.

Authors:  Sudha Ponnusamy; Saikat Haldar; Fayaj Mulani; Smita Zinjarde; Hirekodathakallu Thulasiram; Ameeta RaviKumar
Journal:  PLoS One       Date:  2015-10-15       Impact factor: 3.240

5.  Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives.

Authors:  Veronika Sidova; Pavel Zoufaly; Jan Pokorny; Petr Dzubak; Marian Hajduch; Igor Popa; Milan Urban
Journal:  PLoS One       Date:  2017-02-03       Impact factor: 3.240

6.  Study of the in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of medicinal plants from Saudi Arabia.

Authors:  Nawal M Al-Musayeib; Ramzi A Mothana; Shaza Al-Massarani; An Matheeussen; Paul Cos; Louis Maes
Journal:  Molecules       Date:  2012-09-25       Impact factor: 4.411

7.  Antiplasmodial Potential of the African Mistletoe: Agelanthus dodoneifolius Polh and Wiens.

Authors:  M I Builders; M O Uguru; C Aguiyi
Journal:  Indian J Pharm Sci       Date:  2012-05       Impact factor: 0.975

8.  Antiplasmodial and cytotoxic activities of the constituents of Turraea robusta and Turraea nilotica.

Authors:  Beatrice N Irungu; Nicholas Adipo; Jennifer A Orwa; Francis Kimani; Matthias Heydenreich; Jacob O Midiwo; Per Martin Björemark; Mikael Håkansson; Abiy Yenesew; Máté Erdélyi
Journal:  J Ethnopharmacol       Date:  2015-08-28       Impact factor: 4.360

9.  Neemazal ® as a possible alternative control tool for malaria and African trypanosomiasis?

Authors:  R Serge Yerbanga; Jean-Baptiste Rayaisse; Amélie Vantaux; Ernest Salou; Karine Mouline; François Hien; Annette Habluetzel; Roch K Dabiré; Jean Bosco Ouédraogo; Philippe Solano; Thierry Lefèvre
Journal:  Parasit Vectors       Date:  2016-05-04       Impact factor: 3.876

10.  Transmission blocking activity of Azadirachta indica and Guiera senegalensis extracts on the sporogonic development of Plasmodium falciparum field isolates in Anopheles coluzzii mosquitoes.

Authors:  Rakiswendé S Yerbanga; Leonardo Lucantoni; Robert K Ouédraogo; Dari F Da; Franck A Yao; Koudraogo B Yaméogo; Thomas S Churcher; Giulio Lupidi; Orazio Taglialatela-Scafati; Louis Clément Gouagna; Anna Cohuet; George K Christophides; Jean Bosco Ouédraogo; Annette Habluetzel
Journal:  Parasit Vectors       Date:  2014-04-15       Impact factor: 3.876
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